{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:57:41Z","timestamp":1770037061132,"version":"3.49.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"unspecified","delay-in-days":23,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115000584_sec1\"><jats:title>Objective:<\/jats:title><jats:p>This retrospective study aimed to evaluate the effective closure rate for spontaneous cerebrospinal fluid leaks with functional endoscopic sinus surgery and identify patient characteristics that may be associated with a need for additional therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000584_sec2\"><jats:title>Method:<\/jats:title><jats:p>A retrospective analysis of patients with spontaneous cerebrospinal fluid leaks was performed. Data on the nature of presentation, patient body mass index, defect location and size, intracranial pressure, clinical follow up, and complications were collected.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000584_sec3\"><jats:title>Results:<\/jats:title><jats:p>Twenty-five patients had spontaneous cerebrospinal fluid leaks with evidence of idiopathic intracranial hypertension. The most common sites were the cribriform plate, followed by the ethmoid roof and sphenoid lateral pterygoid recess. All patients underwent endonasal endoscopic surgery to repair the defect. Post-operatively, all patients underwent lumbar drainage and acetazolamide therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000584_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Spontaneous cerebrospinal fluid leaks represent a surgical challenge because of their high recurrence rates. 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