{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:41:49Z","timestamp":1791830509436,"version":"4.3.4"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"S3","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115000808_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>To investigate the effectiveness of benzodiazepine use for subjective tinnitus and to consider this in the context of the concomitant side effects.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000808_sec2\"><jats:title>Methods:<\/jats:title><jats:p>A systematic search of several databases using the terms \u2018tinnitus\u2019 and \u2018benzodiazepines\u2019 was conducted to find clinical trials of benzodiazepines and comparators in tinnitus patients. These studies were then assessed for risk of bias.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000808_sec3\"><jats:title>Results:<\/jats:title><jats:p>Six clinical trials were included. Clonazepam was found to be effective in three studies, but these studies had limitations regarding adequate blinding. The effectiveness of alprazolam was equivocal. Diazepam was not effective in two studies and oxazepam was effective in one study.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000808_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Benzodiazepine use for subjective tinnitus does not have a robust evidence base. Clonazepam has the most evidence to support its use and is relatively less likely to lead to abuse because of its longer half-life, but caution is still needed given the other serious side effects.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115000808","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T07:11:47Z","timestamp":1437462707000},"page":"S14-S22","source":"Crossref","is-referenced-by-count":36,"title":["The use of benzodiazepines for tinnitus: systematic review"],"prefix":"10.1017","volume":"129","author":[{"given":"N E","family":"Jufas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"S0022215115000808_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S1755146300090600"},{"key":"S0022215115000808_ref9","volume-title":"Trends in Alcohol and Drug Related Ambulance Attendances in Victoria 2012\/13","author":"Lloyd","year":"2014"},{"key":"S0022215115000808_ref8","volume-title":"Finding into Death with Inquest: Inquest in the Death of David Andrew Trengrove","year":"2012"},{"key":"S0022215115000808_ref13","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2011"},{"key":"S0022215115000808_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-001-0112-9"},{"key":"S0022215115000808_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302273"},{"key":"S0022215115000808_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"S0022215115000808_ref1","doi-asserted-by":"publisher","DOI":"10.2174\/1874205X01105010012"},{"key":"S0022215115000808_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00160-3"},{"key":"S0022215115000808_ref3","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895267"},{"key":"S0022215115000808_ref36","first-page":"50","article-title":"Clonazepam in the pharmacological treatment of vertigo and tinnitus","volume":"8","author":"Gananca","year":"2002","journal-title":"Int Tinnitus J"},{"key":"S0022215115000808_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00168-8"},{"key":"S0022215115000808_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880200042006"},{"key":"S0022215115000808_ref25","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2003.01254.x"},{"key":"S0022215115000808_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082995"},{"key":"S0022215115000808_ref16","doi-asserted-by":"publisher","DOI":"10.3109\/03005368109081425"},{"key":"S0022215115000808_ref17","first-page":"P155","article-title":"The effects of alprazolam on tinnitus: a cross-over randomized clinical trial","volume":"15","author":"Jalali","year":"2009","journal-title":"Med Sci Monit"},{"key":"S0022215115000808_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)30088-4"},{"key":"S0022215115000808_ref14","first-page":"140","article-title":"Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin","volume":"12","author":"Bahmad","year":"2006","journal-title":"Int Tinnitus J"},{"key":"S0022215115000808_ref21","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200617"},{"key":"S0022215115000808_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66050-6"},{"key":"S0022215115000808_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181cdb2a2"},{"key":"S0022215115000808_ref27","unstructured":"Royal Australian and New Zealand College of Psychiatrists. 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