{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:08Z","timestamp":1786999568916,"version":"build-2736575974"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215115000845_sec1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the relationship between severe tinnitus and inflammation using the neutrophil-to-lymphocyte ratio as a marker of stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215115000845_sec2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 107 patients who had been suffering with severe tinnitus (tinnitus handicap inventory scale grades of 3\u20135) for at least 2 weeks were recruited. Patients underwent detailed ENT examinations and audiometric tests to exclude a relevant pathological cause of the tinnitus. Patients with systemic diseases, malignancy or inflammatory diseases that could alter neutrophil-to-lymphocyte ratio were excluded. A total of 107 age- and sex-matched healthy control participants were also recruited. Routine laboratory test results and neutrophil-to-lymphocyte ratio were compared between the patients and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215115000845_sec3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Lipid profile, liver function, white blood cell count, haemoglobin level, mean corpuscular volume, and vitamin B12 and folate levels were similar among the patients and controls. However, mean neutrophil-to-lymphocyte ratio was significantly higher among the patients than the controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215115000845_sec4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of this novel study suggest that neutrophil-to-lymphocyte ratio should be considered during the evaluation of tinnitus patients as a potential clinical marker of tinnitus. Further studies are required to verify the findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215115000845","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T06:41:22Z","timestamp":1435819282000},"page":"544-547","source":"Crossref","is-referenced-by-count":23,"title":["Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study"],"prefix":"10.1017","volume":"129","author":[{"given":"I","family":"Ozbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H H","family":"Balikci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kucur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N K","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Ozkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Oghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"S0022215115000845_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.831024"},{"key":"S0022215115000845_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.08.006"},{"key":"S0022215115000845_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23565"},{"key":"S0022215115000845_ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045599"},{"key":"S0022215115000845_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20329"},{"key":"S0022215115000845_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.641514"},{"key":"S0022215115000845_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2785-5"},{"key":"S0022215115000845_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20138"},{"key":"S0022215115000845_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00047"},{"key":"S0022215115000845_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2715-6"},{"key":"S0022215115000845_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.12.006"},{"key":"S0022215115000845_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.004"},{"key":"S0022215115000845_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.006"},{"key":"S0022215115000845_ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613515071"},{"key":"S0022215115000845_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/19.4.889"},{"key":"S0022215115000845_ref1","first-page":"16","volume-title":"Tinnitus: Theory and Management","author":"Hoffman","year":"2004"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215115000845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T20:22:56Z","timestamp":1555791776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215115000845\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0022215115000845"],"URL":"https:\/\/doi.org\/10.1017\/s0022215115000845","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}