{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:17:21Z","timestamp":1774909041164,"version":"3.50.1"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115001590_sec_a1\"><jats:title>Introduction:<\/jats:title><jats:p>The role played by<jats:italic>Mycoplasma pneumoniae<\/jats:italic>and<jats:italic>Chlamydophila pneumoniae<\/jats:italic>in the pathogenesis of chronic rhinosinusitis with nasal polyps has been the object of ongoing debate. We used real-time polymerase chain reaction to investigate the prevalence of both microorganisms in the nasal tissue samples of patients and controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001590_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>We extracted DNA from nasal polyp samples obtained during functional endoscopic sinus surgery and the inferior turbinate samples of controls undergoing septoplasty. We used the highly sensitive real-time polymerase chain reaction to detect the presence of<jats:italic>M pneumoniae<\/jats:italic>and<jats:italic>C pneumoniae<\/jats:italic>DNA.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001590_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Patients with chronic rhinosinusitis with nasal polyps consisted of 62 individuals (39 men; mean age 51 years); the control group consisted of 24 individuals (13 men; mean age 45 years). All samples from both groups were negative for<jats:italic>M pneumoniae<\/jats:italic>and<jats:italic>C pneumoniae<\/jats:italic>DNA.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001590_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>We have demonstrated that the likelihood of<jats:italic>M pneumoniae<\/jats:italic>and<jats:italic>C pneumoniae<\/jats:italic>acting as an ongoing inflammatory stimulus in chronic rhinosinusitis with nasal polyps is slim.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115001590","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T10:01:54Z","timestamp":1438250514000},"page":"865-869","source":"Crossref","is-referenced-by-count":2,"title":["<i>Mycoplasma pneumoniae<\/i>and<i>Chlamydophila pneumoniae<\/i>: a comparative study in patients with nasal polyposis and healthy controls"],"prefix":"10.1017","volume":"129","author":[{"given":"D G","family":"Ioannidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V A","family":"Lachanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Florou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Bizakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Petinaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C E","family":"Skoulakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"S0022215115001590_ref22","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2012.32.2.133"},{"key":"S0022215115001590_ref17","first-page":"754","article-title":"Role of C. 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