{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:16:12Z","timestamp":1773422172238,"version":"3.50.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115001607_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>The postulated sites of perilymph fistulae involve otic capsule deficiencies, in particular, at the fissula ante fenestram. Histological studies have revealed this to be a channel extending from the middle ear, and becoming continuous with the inner ear medial to the anterior limit of the oval window. The relationship between a patent fissula and symptoms of perilymph fistula is contentious.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001607_sec_a2\"><jats:title>Objective:<\/jats:title><jats:p>The understanding of the anatomy of the fissula ante fenestram is incomplete. Histopathology is inherently destructive to the delicate ultrastructure of the middle and inner ear. Conversely, X-ray microtomography allows non-destructive examination of the otic capsule. In this study, we used X-ray microtomography to characterise the fissula ante fenestram.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001607_sec_a3\"><jats:title>Materials and methods:<\/jats:title><jats:p>We imaged cadaveric temporal bones with X-ray microtomography. We used the Avizo Fire (Visualization Science Group, Merignac Cedex, France) software to perform post-processing and image analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001607_sec_a4\"><jats:title>Results:<\/jats:title><jats:p>Three-dimensional modelling of the fissula ante fenestram allowed stratification into four forms: rudimentary pit; partial fissula; complete occluded fissula; and complete patent fissula.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001607_sec_a5\"><jats:title>Conclusion:<\/jats:title><jats:p>X-ray microtomography showed that the fissula ante fenestram is present in various forms from rudimentary pit to complete deficiency of the otic capsule. This understanding may have implications for otologic surgery and clinical diagnosis of perilymph fistula.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115001607","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T05:29:21Z","timestamp":1438752561000},"page":"840-851","source":"Crossref","is-referenced-by-count":2,"title":["X-ray microtomography study of otic capsule deficiencies: three-dimensional modelling of the fissula ante fenestram"],"prefix":"10.1017","volume":"129","author":[{"given":"J W","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Sale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"S0022215115001607_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1935.00640020313007"},{"key":"S0022215115001607_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1933.03580060005001"},{"key":"S0022215115001607_ref12","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109131370"},{"key":"S0022215115001607_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1943.00670030664005"},{"key":"S0022215115001607_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700501"},{"key":"S0022215115001607_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100094238"},{"key":"S0022215115001607_ref22","doi-asserted-by":"publisher","DOI":"10.1177\/000348947808700603"},{"key":"S0022215115001607_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200310000-00006"},{"key":"S0022215115001607_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00469735"},{"key":"S0022215115001607_ref11","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198601000-00007"},{"key":"S0022215115001607_ref20","first-page":"214","article-title":"Ricerche anatomiche intorno alla capsula del labirinto [in Italian]","volume":"31","author":"Perozzi","year":"1921","journal-title":"Arch Ital Otol Rinol Laringol"},{"key":"S0022215115001607_ref1","first-page":"38","article-title":"Perilymphatic fistulae: more than a century of notions, conjectures, and critical studies","volume":"13","author":"Kohut","year":"1992","journal-title":"Am J Otol"},{"key":"S0022215115001607_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100115580"},{"key":"S0022215115001607_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090560408"},{"key":"S0022215115001607_ref2","first-page":"261","article-title":"A critical appraisal of spontaneous perilymphatic fistulas of the inner ear","volume":"20","author":"Friedland","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215115001607_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000217"},{"key":"S0022215115001607_ref19","doi-asserted-by":"publisher","DOI":"10.3109\/00016483509118119"},{"key":"S0022215115001607_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600108"},{"key":"S0022215115001607_ref6","volume-title":"Surgical Anatomy of the Temporal Bone and Ear","author":"Anson","year":"1973"},{"key":"S0022215115001607_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600951509"},{"key":"S0022215115001607_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509125236"},{"key":"S0022215115001607_ref21","first-page":"815","article-title":"Validity of spontaneous perilymphatic fistula","volume":"16","author":"Cole","year":"1995","journal-title":"Am J Otol"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215115001607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T20:10:13Z","timestamp":1555791013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215115001607\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0022215115001607"],"URL":"https:\/\/doi.org\/10.1017\/s0022215115001607","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}