{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:13:09Z","timestamp":1784693589905,"version":"3.55.0"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T00:00:00Z","timestamp":1436745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115001735_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001735_sec_a2\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D<jats:sub>1<\/jats:sub>, cyclin D<jats:sub>3<\/jats:sub>and Ki-67, in vestibular schwannoma patients separated into two age groups: \u226440 years or &gt;40 years.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001735_sec_a3\"><jats:title>Method:<\/jats:title><jats:p>Immunohistochemical detection of cyclin D<jats:sub>1<\/jats:sub>, cyclin D<jats:sub>3<\/jats:sub>and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001735_sec_a4\"><jats:title>Results:<\/jats:title><jats:p>The proliferation index of vestibular schwannomas was statistically higher in the \u226440 years age group compared to that in the &gt;40 years age group (mean of 4.52<jats:italic>vs<\/jats:italic>3.27, respectively;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Overexpression of cyclin D<jats:sub>1<\/jats:sub>and cyclin D<jats:sub>3<\/jats:sub>was found in 68 per cent and 44 per cent of tumours, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001735_sec_a5\"><jats:title>Conclusion:<\/jats:title><jats:p>There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D<jats:sub>1<\/jats:sub>and cyclin D<jats:sub>3<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115001735","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T06:35:04Z","timestamp":1436769304000},"page":"S2-S10","source":"Crossref","is-referenced-by-count":6,"title":["Role of cyclins D1 and D3 in vestibular 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