{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:17:29Z","timestamp":1780615049803,"version":"3.54.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115001747_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001747_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic>= 178) were assigned to five groups according to apnoea\u2013hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001747_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndrome patients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndrome patients (group 2) and patients treated with continuous positive airway pressure (group 5) (<jats:italic>p<\/jats:italic>= 0.008,<jats:italic>p<\/jats:italic>= 0.008 and<jats:italic>p<\/jats:italic>= 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (<jats:italic>p<\/jats:italic>= 0.0005,<jats:italic>p<\/jats:italic>= 0.011 and<jats:italic>p<\/jats:italic>= 0.001). There was a positive correlation between apnoea\u2013hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758,<jats:italic>p<\/jats:italic>= 0.034), and a negative correlation between apnoea\u2013hypopnea index and minimum oxygen saturation (r = \u22120.179,<jats:italic>p<\/jats:italic>= 0.012).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115001747_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115001747","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T07:48:23Z","timestamp":1438588103000},"page":"887-892","source":"Crossref","is-referenced-by-count":26,"title":["Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome"],"prefix":"10.1017","volume":"129","author":[{"given":"A","family":"Yenigun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Karamanli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"S0022215115001747_ref1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00111208"},{"key":"S0022215115001747_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.831024"},{"key":"S0022215115001747_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.04.041"},{"key":"S0022215115001747_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-007-0106-1"},{"key":"S0022215115001747_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.10.034"},{"key":"S0022215115001747_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.03.010"},{"key":"S0022215115001747_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.043"},{"key":"S0022215115001747_ref11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5664\/jcsm.3070","article-title":"Serum inflammatory markers in obstructive sleep apnea: a meta-analysis","volume":"9","author":"Nadeem","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"S0022215115001747_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.10.010"},{"key":"S0022215115001747_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74229-X"},{"key":"S0022215115001747_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28536"},{"key":"S0022215115001747_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2004.08.002"},{"key":"S0022215115001747_ref15","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1776"},{"key":"S0022215115001747_ref5","doi-asserted-by":"publisher","DOI":"10.1023\/B:AGEN.0000029415.62384.ba"},{"key":"S0022215115001747_ref8","volume-title":"A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages in Human Subjects","author":"Rechtschaffen","year":"1968"},{"key":"S0022215115001747_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.002"},{"key":"S0022215115001747_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.006"},{"key":"S0022215115001747_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.04.001"},{"key":"S0022215115001747_ref16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1226OC"},{"key":"S0022215115001747_ref9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.4.895"},{"key":"S0022215115001747_ref24","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.641514"},{"key":"S0022215115001747_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0492-2"},{"key":"S0022215115001747_ref17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"S0022215115001747_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.4.499"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215115001747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T20:01:26Z","timestamp":1599422486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215115001747\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,3]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0022215115001747"],"URL":"https:\/\/doi.org\/10.1017\/s0022215115001747","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,3]]}}}