{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:55:19Z","timestamp":1791201319023,"version":"4.2.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115002108_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>This study aimed to investigate the association of C-C chemokine receptor type 9 (CCR9) and C-C motif chemokine 25 (CCL25) expression levels with clinical and tumour\u2013node\u2013metastasis stage in nasopharyngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002108_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A total of 42 nasopharyngeal carcinoma patients (nasopharyngeal carcinoma group) and 18 patients with a normal nasopharynx (control group) were included in this study. Tissues were collected during surgery and medical examinations. The CCR9 and CCL25 messenger RNA and protein levels were measured using quantitative reverse transcription polymerase chain reaction, Western blotting and immunohistochemical analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002108_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>CCR9 and CCL25 messenger RNA and protein levels were significantly increased in the nasopharyngeal carcinoma group compared with the control group (<jats:italic>p<\/jats:italic>&lt; 0.05). Both CCR9 and CCL25 messenger RNA and protein levels were significantly higher in advanced-stage nasopharyngeal carcinoma (stages III and IV) patients compared with early-stage nasopharyngeal carcinoma (stages I and II) patients (<jats:italic>p<\/jats:italic>&lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002108_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>The extent of CCR9 and CCL25 upregulation in nasopharyngeal carcinoma correlates with the tumour\u2013node\u2013metastasis stage.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115002108","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T09:50:03Z","timestamp":1439805003000},"page":"1013-1019","source":"Crossref","is-referenced-by-count":7,"title":["Intracellular expression profile and clinical significance of the CCR9\u2013CCL25 chemokine receptor complex in nasopharyngeal carcinoma"],"prefix":"10.1017","volume":"129","author":[{"given":"L-F","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-P","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,8,17]]},"reference":[{"key":"S0022215115002108_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.028225"},{"key":"S0022215115002108_ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02157.x"},{"key":"S0022215115002108_ref8","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.162.10.5671","article-title":"Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK","volume":"162","author":"Zaballos","year":"1999","journal-title":"J Immunol"},{"key":"S0022215115002108_ref7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011284"},{"key":"S0022215115002108_ref21","doi-asserted-by":"publisher","DOI":"10.3109\/14653241003631815"},{"key":"S0022215115002108_ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.6828888"},{"key":"S0022215115002108_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90740-9"},{"key":"S0022215115002108_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930330310"},{"key":"S0022215115002108_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-1"},{"key":"S0022215115002108_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3181572b3a"},{"key":"S0022215115002108_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"S0022215115002108_ref5","first-page":"540","article-title":"Cancer and the chemokine network","volume":"4","author":"Balkwill","year":"2004","journal-title":"Nature"},{"key":"S0022215115002108_ref6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.5069"},{"key":"S0022215115002108_ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215988"},{"key":"S0022215115002108_ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.3668"},{"key":"S0022215115002108_ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1812"},{"key":"S0022215115002108_ref14","volume-title":"International Union Against Cancer. 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