{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:24:07Z","timestamp":1783765447594,"version":"3.55.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115002881_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>The nasal cycle exhibits mainly reciprocal changes in nasal airflow that may be controlled from centres in the hypothalamus and brainstem. This study aims to gather new knowledge about the nasal cycle to help develop a control model.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002881_sec_a2\"><jats:title>Method:<\/jats:title><jats:p>Right and left nasal airflow was measured in healthy human subjects by rhinomanometry. This was performed over 7-hour periods on 2 study days separated by approximately 1 week. The correlation coefficient for nasal airflow was calculated for day 1 and day 2.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002881_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Thirty subjects (mean age, 22.7 years) completed the study. The correlation coefficient for nasal airflow varied between r = 0.97 with in-phase changes in airflow and r = \u22120.89 with reciprocal changes in airflow. The majority of r values were negative, indicating reciprocal changes in airflow (50 out of 60). There was a tendency for r values to become more negative between day 1 and day 2 (<jats:italic>p<\/jats:italic>&lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002881_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>A control model involving a hypothalamic centre and two brainstem half centres is proposed to explain both the in-phase and reciprocal changes in airflow associated with the nasal cycle.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115002881","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T04:41:45Z","timestamp":1445316105000},"page":"82-88","source":"Crossref","is-referenced-by-count":25,"title":["A model for the central control of airflow patterns within the human nasal cycle"],"prefix":"10.1017","volume":"130","author":[{"given":"M","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eccles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"S0022215115002881_ref20","first-page":"25","article-title":"Nasal swell bodies and cyclic changes in the air passages of the rat and rabbit nose","volume":"110","author":"Bojsen-Moller","year":"1971","journal-title":"J Anat"},{"key":"S0022215115002881_ref16","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000388"},{"key":"S0022215115002881_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109138490"},{"key":"S0022215115002881_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809121472"},{"key":"S0022215115002881_ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00432.x"},{"key":"S0022215115002881_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)00123-2"},{"key":"S0022215115002881_ref1","first-page":"101","article-title":"Exact measurement of the air conductance in the nose [in German]","volume":"3","author":"Kayser","year":"1895","journal-title":"Archiv fur Laryngol Rhinol"},{"key":"S0022215115002881_ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00016489409126084"},{"key":"S0022215115002881_ref18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4193\/Rhino10.065","article-title":"A guide to practical aspects of measurement of human nasal airflow by rhinomanometry","volume":"49","author":"Eccles","year":"2011","journal-title":"Rhinology"},{"key":"S0022215115002881_ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00016485309132516"},{"key":"S0022215115002881_ref19","first-page":"169","article-title":"Consensus report on acoustic rhinometry and rhinomanometry","volume":"43","author":"Clement","year":"2005","journal-title":"Rhinology"},{"key":"S0022215115002881_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198709000-00024"},{"key":"S0022215115002881_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582915"},{"key":"S0022215115002881_ref12","doi-asserted-by":"publisher","DOI":"10.2500\/105065895781873872"},{"key":"S0022215115002881_ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709109065"},{"key":"S0022215115002881_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-192708000-00008"},{"key":"S0022215115002881_ref7","doi-asserted-by":"publisher","DOI":"10.15197\/sabad.1.11.01"},{"key":"S0022215115002881_ref14","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000707"},{"key":"S0022215115002881_ref17","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113443"},{"key":"S0022215115002881_ref15","first-page":"150","article-title":"Sympathetic control of nasal erectile tissue","volume":"128","author":"Eccles","year":"1983","journal-title":"Eur J Respir Dis Suppl"},{"key":"S0022215115002881_ref9","doi-asserted-by":"publisher","DOI":"10.3109\/00016485309132517"},{"key":"S0022215115002881_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24546"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215115002881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T17:46:28Z","timestamp":1653327988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215115002881\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0022215115002881"],"URL":"https:\/\/doi.org\/10.1017\/s0022215115002881","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}