{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T13:38:55Z","timestamp":1648820335027},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115002959_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>Azelastine nasal spray is a topical antihistaminic drug for the symptomatic treatment of allergic rhinitis. This study aimed to investigate the effects of azelastine on nasal and nasopharyngeal microflora.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002959_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Swab samples from 25 patients prescribed azelastine nasal spray monotherapy were collected just before treatment and after 1 month of treatment. After incubation of inoculates, the number of bacteria present in cultures was measured (in colony-forming units per millilitre).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002959_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Evaluation of the number of microflora revealed increased bacterial reproduction after treatment, but this difference was not statistically significant. The use of azelastine nasal spray decreased the reproduction of three potentially pathogenic bacteria; however, it did not affect the reproduction of other potentially pathogenic bacteria.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115002959_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>The use of azelastine nasal spray for one month did not have a statistically significant effect on the numbers of nasal and nasopharyngeal microflora; it is therefore safe from a microbiological viewpoint.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115002959","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T03:17:27Z","timestamp":1446175047000},"page":"95-99","source":"Crossref","is-referenced-by-count":0,"title":["Effects of azelastine nasal spray on nasal and nasopharyngeal microflora"],"prefix":"10.1017","volume":"130","author":[{"given":"F","family":"Aksoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Veyseller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Ozturan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"G\u00f6n\u00fcll\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"S0022215115002959_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00730.x"},{"key":"S0022215115002959_ref3","first-page":"1184","article-title":"Pharmacological and toxicological properties of azelastine, a novel anti-allergic agent","volume":"31","author":"Zechel","year":"1981","journal-title":"Arzneimittelforschung"},{"key":"S0022215115002959_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF03257397"},{"key":"S0022215115002959_ref11","first-page":"1143","article-title":"Effects of azelastine on the level of serum interleukin-4 and soluble CD23 antigen in the treatment of nasal allergy","volume":"48","author":"Ito","year":"1998","journal-title":"Arzneimittelforschung"},{"key":"S0022215115002959_ref1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.38"},{"key":"S0022215115002959_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80196-5"},{"key":"S0022215115002959_ref21","unstructured":"Beck G , Mansur A , Afzal M Effect of azelastine nasal spray on mediators of inflammation in patients with seasonal allergic rhinitis (SAR). 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