{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:08:09Z","timestamp":1776352089098,"version":"3.51.2"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients.<\/jats:p><\/jats:sec>Methods:<\/jats:title>Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed with head and neck carcinoma.<\/jats:p><\/jats:sec>Results:<\/jats:title>Approximately 53 per cent of patients were diagnosed with radiation-induced hypothyroidism. Its occurrence was related to: tumour location, laryngeal surgery type, neck dissection type, post-operative complications, cervical radiotherapy and radiotherapy unit type (linear particle accelerator or telecobalt therapy technology).<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Control of thyroid function should be standardised for several years after treatment, particularly in patients with risk factors, such as those treated with telecobalt therapy, those with post-operative complications and for whom the thyroid parenchyma is included in the irradiated area (laryngeal or pharyngeal location and bilateral cervical radiation).<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116000967","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T04:23:58Z","timestamp":1458015838000},"page":"478-481","source":"Crossref","is-referenced-by-count":22,"title":["Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study"],"prefix":"10.1017","volume":"130","author":[{"given":"J R","family":"Alba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Basterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Santonja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Zapater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"S0022215116000967_ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1021"},{"key":"S0022215116000967_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0797-3"},{"key":"S0022215116000967_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.12.003"},{"key":"S0022215116000967_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00276-0"},{"key":"S0022215116000967_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.5.652"},{"key":"S0022215116000967_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.029"},{"key":"S0022215116000967_ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.19593"},{"key":"S0022215116000967_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23307"},{"key":"S0022215116000967_ref7","first-page":"182","article-title":"Subclinical hypothyroidism: to treat or not to treat? 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