{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:47:41Z","timestamp":1784314061385,"version":"3.55.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116000992_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116000992_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin, and intraperitoneal N-acetylcysteine after intratympanic gentamicin. Signal-to-noise ratio and distortion product otoacoustic emissions were evaluated in all groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116000992_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 2, 3, 4 and 6 kHz, as determined by the distortion product otoacoustic emission measurements. According to the signal-to-noise measurements, N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 3, 6 and 8 kHz.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116000992_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Gentamicin-induced hearing loss in rats may be prevented by the concomitant use of vitamin A and N-acetylcysteine. Specifically, N-acetylcysteine appeared to have a more protective effect than vitamin A for a greater range of noise frequencies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116000992","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T08:55:27Z","timestamp":1461142527000},"page":"440-446","source":"Crossref","is-referenced-by-count":17,"title":["Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A"],"prefix":"10.1017","volume":"130","author":[{"given":"I","family":"Aladag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Guven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Songu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"S0022215116000992_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01130-X"},{"key":"S0022215116000992_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817d01cd"},{"key":"S0022215116000992_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00031"},{"key":"S0022215116000992_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200107000-00005"},{"key":"S0022215116000992_ref11","first-page":"236","article-title":"Are intratympanic injections of N-acetylcysteine and methylprednisolone protective against cisplatin-induced ototoxicity?","volume":"39","author":"Saliba","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215116000992_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00385-4"},{"key":"S0022215116000992_ref25","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.280202.x"},{"key":"S0022215116000992_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000186799.45377.63"},{"key":"S0022215116000992_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08643.x"},{"key":"S0022215116000992_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(90)90151-E"},{"key":"S0022215116000992_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(96)80013-X"},{"key":"S0022215116000992_ref26","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-72992003000400011"},{"key":"S0022215116000992_ref9","first-page":"521","article-title":"Effect of high-dose cisplatin on auditory brainstem responses and otoacoustic emissions in laboratory animals","volume":"21","author":"Sockalingam","year":"2000","journal-title":"Am J Otol"},{"key":"S0022215116000992_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000254"},{"key":"S0022215116000992_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000013777"},{"key":"S0022215116000992_ref14","doi-asserted-by":"publisher","DOI":"10.2399\/jmu.2014001005"},{"key":"S0022215116000992_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002299"},{"key":"S0022215116000992_ref24","volume-title":"Fennema's Food Chemistry","author":"Damodaran","year":"2008"},{"key":"S0022215116000992_ref18","first-page":"9","article-title":"PAST: paleontological statistics software package for education and data analysis","volume":"4","author":"Hammer","year":"2001","journal-title":"Palaeontol Electron"},{"key":"S0022215116000992_ref12","first-page":"843","article-title":"Lipid peroxidation is associated with the inhibitory action of all-trans-retinoic acid on mammary cell transformation","volume":"20","author":"Kubow","year":"2000","journal-title":"Anticancer Res"},{"key":"S0022215116000992_ref3","doi-asserted-by":"publisher","DOI":"10.1121\/1.382104"},{"key":"S0022215116000992_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802226155"},{"key":"S0022215116000992_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.09.028"},{"key":"S0022215116000992_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.114"},{"key":"S0022215116000992_ref2","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.10733"},{"key":"S0022215116000992_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"S0022215116000992_ref1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10850"}],"container-title":["The Journal of Laryngology &amp; 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