{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:47:15Z","timestamp":1782488835785,"version":"3.54.5"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116008598_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008598_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A total of 120 otomycosis patients were randomly assigned to receive either 1 per cent clotrimazole solution (intervention group) or 3 per cent boric acid in 70 per cent alcohol (control group) at the Khon Kaen Hospital ENT out-patient department. Treatment effectiveness was determined based on the otomicroscopic absence of fungus one week after therapy, following a single application of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008598_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>After 1 week of treatment, there were data for 109 participants, 54 in the clotrimazole group and 55 in the boric acid group. The absolute difference in cure rates between 1 per cent clotrimazole solution and 3 per cent boric acid in 70 per cent alcohol was 17.9 per cent (95 per cent confidence interval, 2.3 to 33.5; <jats:italic>p<\/jats:italic> = 0.028) and the number needed to treat was 6 (95 per cent confidence interval, 3.0 to 43.4). Adverse events for the two agents were comparable.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008598_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>One per cent clotrimazole solution is more effective than 3 per cent boric acid in 70 per cent alcohol for otomycosis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116008598","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T08:15:14Z","timestamp":1470039314000},"page":"811-815","source":"Crossref","is-referenced-by-count":18,"title":["Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial"],"prefix":"10.1017","volume":"130","author":[{"given":"S","family":"Romsaithong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tomanakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Tangsawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Thanaviratananich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"S0022215116008598_ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.0933-7407.2001.00682.x"},{"key":"S0022215116008598_ref5","first-page":"78","article-title":"Efficacy of topical clotrimazole in treatment of otomycosis","volume":"25","author":"Khan","year":"2013","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"S0022215116008598_ref13","first-page":"34","article-title":"Treatment outcome of otomycosis in Ilorin, Nigeria","volume":"21","author":"Ologe","year":"2002","journal-title":"West Afr J Med"},{"key":"S0022215116008598_ref8","unstructured":"Efficacy of Tincture merthiolate vs 3% Boric acid in treatment of otomycosis [in Thai]. In: http:\/\/med.mahidol.ac.th\/ent\/sites\/default\/files\/public\/pdf\/AbstractPornsilINAL%20otomycosis...pdf [31 May 2015]"},{"key":"S0022215116008598_ref14","doi-asserted-by":"publisher","DOI":"10.1023\/B:MYCO.0000003574.89032.99"},{"key":"S0022215116008598_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.01.022"},{"key":"S0022215116008598_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.07.008"},{"key":"S0022215116008598_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.003"},{"key":"S0022215116008598_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436569"},{"key":"S0022215116008598_ref7","doi-asserted-by":"publisher","DOI":"10.1258\/002221503321046621"},{"key":"S0022215116008598_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.12.005"},{"key":"S0022215116008598_ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2002.00737.x"},{"key":"S0022215116008598_ref1","first-page":"66","article-title":"Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy","volume":"3","author":"Moghadam","year":"2010","journal-title":"Jundishapur J Microbiol"},{"key":"S0022215116008598_ref11","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011909486"},{"key":"S0022215116008598_ref16","doi-asserted-by":"publisher","DOI":"10.17656\/jzs.10209"},{"key":"S0022215116008598_ref9","first-page":"765","article-title":"A contribution to the treatment of otomycoses [in German]","volume":"55","author":"Kley","year":"1976","journal-title":"Laryngol Rhinol Otol (Stuttg)"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215116008598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T23:50:26Z","timestamp":1555631426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215116008598\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0022215116008598"],"URL":"https:\/\/doi.org\/10.1017\/s0022215116008598","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]}}}