{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T18:07:47Z","timestamp":1766945267438},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116008707_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>To verify the effectiveness and safety of the addition of adipose-derived regenerative cells to autologous fat injection therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008707_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Unilateral vocal fold paralysis models were made by cutting the right recurrent laryngeal nerve in two pigs. At day 30, 0.5 ml adipose-derived regenerative cells mixed with 1 ml autologous fat was injected into the right vocal fold of one pig, with the other receiving 0.5 ml Ringer's solution mixed with 1 ml autologous fat. At day 120, fibrescopy, laser Doppler flowmeter, computed tomography, vocal function evaluation and histological assessment were conducted.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008707_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Although histological assessment revealed atrophy of the thyroarytenoid muscle fibre in both pigs, there was remarkable hypertrophy of the thyroarytenoid muscle fibre in the area surrounding the adipose-derived regenerative cells injection site.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116008707_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>The addition of a high concentration of adipose-derived regenerative cells to autologous fat injection therapy has the potential to improve the treatment outcome for unilateral vocal fold 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