{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:00:39Z","timestamp":1780574439727,"version":"3.54.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116009063_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the effect of pre- and post-admission antibiotic treatment in paediatric acute mastoiditis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009063_sec_a2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009063_sec_a3\"><jats:title>Method:<\/jats:title><jats:p>Eighty-eight children with acute mastoiditis, from 2003 to 2012, were studied to investigate the effect of antibiotic therapy on short and long-term sequelae.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009063_sec_a4\"><jats:title>Results:<\/jats:title><jats:p>The median period of antibiotic therapy immediately following hospital discharge was 10 days (range, 5\u201349 days; standard deviation = 7.46). There were no sequelae within the fortnight following antibiotic therapy completion, but 14 of 40 patients had significant sequelae thereafter, including recurrent otorrhoea, acute otitis media and ventilation tube insertion requirement. Complication rates were significantly higher among patients who had pre-admission antibiotic therapy (52 per cent), compared to patients previously untreated (27 per cent).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009063_sec_a5\"><jats:title>Conclusion:<\/jats:title><jats:p>Paediatric acute mastoiditis patients treated with antibiotic therapy prior to admission are at higher risk for complication development. The advised time period for oral antibiotic therapy following hospital discharge remains as 10 days in all cases of uncomplicated acute mastoiditis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116009063","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T11:13:49Z","timestamp":1476702829000},"page":"S12-S17","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic effect of pre- and post-admission antibiotic treatment in paediatric acute mastoiditis"],"prefix":"10.1017","volume":"131","author":[{"given":"E","family":"Carmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Curotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"S0022215116009063_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31817f736b"},{"key":"S0022215116009063_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.07.002"},{"key":"S0022215116009063_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05283-2.00141-5"},{"key":"S0022215116009063_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.02.042"},{"key":"S0022215116009063_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.04.009"},{"key":"S0022215116009063_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0755-7.00632-1"},{"key":"S0022215116009063_ref1","first-page":"435","volume-title":"Glasscock-Shambaugh Surgery of the Ear","author":"Gross","year":"2003"},{"key":"S0022215116009063_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107009929"},{"key":"S0022215116009063_ref10","doi-asserted-by":"publisher","DOI":"10.1148\/rg.232025076"},{"key":"S0022215116009063_ref15","first-page":"337","article-title":"Acute mastoiditis: increase of incidence and controversies in antibiotic treatment [in Spanish]","volume":"19","author":"Bartolom\u00e9 Benito","year":"2006","journal-title":"Rev Esp Quimioter"},{"key":"S0022215116009063_ref4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/B978-1-4377-2702-9.00031-3","volume-title":"Principles and Practice of Pediatric Infectious Diseases","author":"Wald","year":"2012"},{"key":"S0022215116009063_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.29"},{"key":"S0022215116009063_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200102000-00004"},{"key":"S0022215116009063_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00425-0"},{"key":"S0022215116009063_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.03.036"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215116009063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T14:28:51Z","timestamp":1657463331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215116009063\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":15,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022215116009063"],"URL":"https:\/\/doi.org\/10.1017\/s0022215116009063","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]}}}