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Otol."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116009294_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>To review research addressing the polymicrobial aetiology of otitis media in Indigenous Australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009294_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Literature review.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009294_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Studies of aspirated middle-ear fluid represented a minor component of the literature reviewed. Most studies relied upon specimens from middle-ear discharge or the nasopharynx. Culture-based middle-ear discharge studies have found that non-typeable<jats:italic>Haemophilus influenzae<\/jats:italic>and<jats:italic>Streptococcus pneumoniae<\/jats:italic>predominate, with<jats:italic>Moraxella catarrhalis, Staphylococcus aureus<\/jats:italic>and<jats:italic>Streptococcus pyogenes<\/jats:italic>isolated in a lower proportion of samples.<jats:italic>Alloiococcus otitidis<\/jats:italic>was detected in a number of studies; however, its role in otitis media pathogenesis remains controversial. Nasopharyngeal colonisation is a risk factor for otitis media in Indigenous infants, and bacterial load of otopathogens in the nasopharynx can predict the ear state of Indigenous children.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009294_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Most studies have used culture-based methods and specimens from middle-ear discharge or the nasopharynx. Findings from these studies are consistent with international literature, but reliance on culture may incorrectly characterise the microbiology of this condition. Advances in genomic technologies are now providing microbiologists with the ability to analyse the entire mixed bacterial communities (\u2018microbiomes\u2019) of samples obtained from Indigenous children with otitis media.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116009294","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T03:47:26Z","timestamp":1484538446000},"page":"S2-S11","source":"Crossref","is-referenced-by-count":15,"title":["Microbiology of otitis media in Indigenous Australian children: review"],"prefix":"10.1017","volume":"131","author":[{"given":"J","family":"Jervis-Bardy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Carney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Duguid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A 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