{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:09:31Z","timestamp":1787846971220,"version":"build-2784847793"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116009324_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009324_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Blood eosinophil numbers and serum interleukin-5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009324_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Blood eosinophil numbers and serum interleukin-5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 \u00b1 26.1 <jats:italic>vs<\/jats:italic> 443.9 \u00b1 76.6 cells\/\u03bcl, <jats:italic>p<\/jats:italic> &lt; 0.05), and decreased significantly after surgery (825.7 \u00b1 26.1 <jats:italic>vs<\/jats:italic> 76.7 \u00b1 25.8 cells\/\u03bcl, <jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009324_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116009324","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T07:51:45Z","timestamp":1478073105000},"page":"1147-1152","source":"Crossref","is-referenced-by-count":20,"title":["Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery"],"prefix":"10.1017","volume":"130","author":[{"given":"A","family":"Honma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Nakamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"S0022215116009324_ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003615"},{"key":"S0022215116009324_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"S0022215116009324_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22507"},{"key":"S0022215116009324_ref3","first-page":"166","article-title":"Evaluation of endoscopic sinus surgery for chronic sinusitis: post-operative erythromycin therapy","volume":"33","author":"Moriyama","year":"1995","journal-title":"Rhinology"},{"key":"S0022215116009324_ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01425.x"},{"key":"S0022215116009324_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(96)80008-3"},{"key":"S0022215116009324_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.068"},{"key":"S0022215116009324_ref6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.801"},{"key":"S0022215116009324_ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.67"},{"key":"S0022215116009324_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.029"},{"key":"S0022215116009324_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70219-2"},{"key":"S0022215116009324_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70005-6"},{"key":"S0022215116009324_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90944-X"},{"key":"S0022215116009324_ref19","first-page":"1350","article-title":"Mucosal eosinophils and l-selectin ligands are associated with invasive and noninvasive sinus surgery outcomes","volume":"171","author":"Myller","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"S0022215116009324_ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013508"},{"key":"S0022215116009324_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000126066"},{"key":"S0022215116009324_ref12","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-OA-0290"},{"key":"S0022215116009324_ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00380.x"},{"key":"S0022215116009324_ref11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van","year":"2006","journal-title":"Allergy"}],"container-title":["The Journal of Laryngology &amp; 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