{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:40:01Z","timestamp":1781858401630,"version":"3.54.5"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116009786_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>Histopathological anomalies of inner-ear structures in individuals with Down syndrome have been well documented; however, few studies have examined the radiological features.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009786_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective study was conducted of temporal bone computed tomography images in 38 individuals (75 ears) with Down syndrome to evaluate the prevalence of inner-ear abnormalities and assess vestibular aqueduct widths.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009786_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Inner-ear anomalies were identified in 20 of the 38 individuals (52.6 per cent). Seven of the 75 temporal bones (9.3 per cent) were found to have higher than previously reported. A dilated internal auditory canal and vestibule were more common among the present study group, while prior studies have demonstrated internal auditory canal stenosis and decreased vestibule size.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116009786_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Down syndrome patients exhibit a high prevalence of dysplastic inner-ear features that confer substantial risk of sensorineural hearing loss. Computed tomography is a useful screening aid to detect inner-ear abnormalities, particularly enlarged vestibular aqueducts, which cause preventable sensorineural hearing loss in this population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116009786","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T06:55:21Z","timestamp":1482908121000},"page":"298-302","source":"Crossref","is-referenced-by-count":16,"title":["Enlarged vestibular aqueducts and other inner-ear abnormalities in patients with Down syndrome"],"prefix":"10.1017","volume":"131","author":[{"given":"C M","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H H","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Kanekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Isildak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"S0022215116009786_ref7","first-page":"467","article-title":"Hearing loss of Down syndrome adults","volume":"85","author":"Keiser","year":"1981","journal-title":"Am J Ment Defic"},{"key":"S0022215116009786_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.09.003"},{"key":"S0022215116009786_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"S0022215116009786_ref13","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1288\/00005537-198110000-00001","article-title":"Down's syndrome \u2013 a modern otorhinolaryngological perspective","volume":"41","author":"Strome","year":"1981","journal-title":"Laryngoscope"},{"key":"S0022215116009786_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811425156"},{"key":"S0022215116009786_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800330059013"},{"key":"S0022215116009786_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.5.723"},{"key":"S0022215116009786_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24375"},{"key":"S0022215116009786_ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1973.00780020172006"},{"key":"S0022215116009786_ref29","first-page":"473","article-title":"Congenital anomalies of the inner ear","volume":"12","author":"Jensen","year":"1974","journal-title":"Radiol Clin North Am"},{"key":"S0022215116009786_ref28","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.51"},{"key":"S0022215116009786_ref27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-0034-1399009","article-title":"Nontumorous enlargement of the internal auditory canal: a risk factor for sensorineural hearing loss? 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