{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:51:42Z","timestamp":1792000302245,"version":"4.4.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221511600983X_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>Mesna (i.e. sodium 2-mercaptoethanesulfonate; C<jats:sub>2<\/jats:sub>H<jats:sub>5<\/jats:sub>NaO<jats:sub>3<\/jats:sub>S<jats:sub>2<\/jats:sub>) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511600983X_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated with saline (saline control group; <jats:italic>n<\/jats:italic> = 10 ears) and propylene glycol plus saline (propylene glycol control group; <jats:italic>n<\/jats:italic> = 10 ears), respectively. In the mesna group, both ears were treated with propylene glycol plus mesna (<jats:italic>n<\/jats:italic> = 20 ears). On days 1, 8 and 15, the saline control group had intratympanic injections of 0.2 ml saline and the propylene glycol control and mesna groups had intratympanic injections of 0.2 ml 100 per cent propylene glycol. On day 22, the propylene glycol control group had a single intratympanic injection of 0.2 ml saline and the mesna group had a single intratympanic injection of 10 per cent mesna. Animals were killed 12 weeks after the last injection and the temporal bones were sent for histopathological evaluation.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511600983X_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>The cholesteatoma formation rate was 88 per cent in the propylene glycol control group, but was significantly lower in the mesna group (<jats:italic>p<\/jats:italic> = 0.01). There were no significant differences in granulation tissue formation (<jats:italic>p<\/jats:italic> = 0.498), cyst formation in the bulla (<jats:italic>p<\/jats:italic> = 0.381), fibrosis (<jats:italic>p<\/jats:italic> = 0.072) and epithelial hyperplasia (<jats:italic>p<\/jats:italic> = 0.081) among experimental groups.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511600983X_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Intratympanic propylene glycol administration is an effective method of promoting experimental cholesteatoma formation. Administration of a single dose of intratympanic mesna inhibited cholesteatoma formation in an animal model.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511600983x","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T10:53:02Z","timestamp":1482231182000},"page":"215-220","source":"Crossref","is-referenced-by-count":12,"title":["Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation"],"prefix":"10.1017","volume":"131","author":[{"given":"O","family":"Ismi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K K","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Vayisoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"S002221511600983X_ref25","doi-asserted-by":"publisher","DOI":"10.3109\/00016480802593489"},{"key":"S002221511600983X_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950180630"},{"key":"S002221511600983X_ref23","first-page":"7","article-title":"Molecular biology of cholesteatoma","volume":"55","author":"Maniu","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"S002221511600983X_ref19","first-page":"30","article-title":"Cochlear effects of intraoperative use of Mesna in cholesteatoma surgery","volume":"85","author":"Vincenti","year":"2014","journal-title":"Acta Biomed"},{"key":"S002221511600983X_ref22","first-page":"8","article-title":"The structure of acquired aural cholesteatoma as revealed by scanning electron microscopy","volume":"67","author":"Miodo\u0144ski","year":"2008","journal-title":"Folia Morphol (Warsz)"},{"key":"S002221511600983X_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200306000-00019"},{"key":"S002221511600983X_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880340058009"},{"key":"S002221511600983X_ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000091472"},{"key":"S002221511600983X_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199804000-00015"},{"key":"S002221511600983X_ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0340-y"},{"key":"S002221511600983X_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992763"},{"key":"S002221511600983X_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000514"},{"key":"S002221511600983X_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(90)90163-P"},{"key":"S002221511600983X_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/mlg.0b013e318031d09d"},{"key":"S002221511600983X_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08659.x"},{"key":"S002221511600983X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(91)90142-3"},{"key":"S002221511600983X_ref4","doi-asserted-by":"publisher","DOI":"10.5319\/wjo.v4.i4.23"},{"key":"S002221511600983X_ref27","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201408079"},{"key":"S002221511600983X_ref12","first-page":"14","article-title":"The effect of naproxen sodium on experimental otitis media","volume":"18","author":"Kayhan","year":"2008","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"S002221511600983X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.01.002"},{"key":"S002221511600983X_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511300011X"},{"key":"S002221511600983X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)30751-5"},{"key":"S002221511600983X_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24890"},{"key":"S002221511600983X_ref15","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2010.485192"},{"key":"S002221511600983X_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2978"},{"key":"S002221511600983X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(95)90059-4"},{"key":"S002221511600983X_ref9","first-page":"214","article-title":"The effect of systemic prednisolone on propylene-glycol induced otitis media in guinea pig","volume":"16","author":"Kayhan","year":"2006","journal-title":"Kulak Burun Bogaz Ihtis Derg"}],"container-title":["The Journal of Laryngology &amp; 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