{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:16:22Z","timestamp":1773094582472,"version":"3.50.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215116010021_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>The optimal management of glottic carcinoma involving the anterior commissure is controversial.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116010021_sec_a2\"><jats:title>Method:<\/jats:title><jats:p>A retrospective analysis was conducted of 76 patients with glottic squamous cell carcinoma treated by transoral carbon dioxide laser resection by a single surgeon.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116010021_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Sixty-three patients (with tumour stage T<jats:sub>is<\/jats:sub>\u2013T<jats:sub>3<\/jats:sub>) were eligible for inclusion. Thirty patients had involvement of the anterior commissure; these patients were significantly more likely to have either uncertain or positive margins (63.3 <jats:italic>vs<\/jats:italic> 30.3 per cent, <jats:italic>p<\/jats:italic> = 0.012), and were also more likely to receive adjuvant radiotherapy (40 <jats:italic>vs<\/jats:italic> 3.2 per cent, <jats:italic>p<\/jats:italic> = 0.0005). The overall laryngeal preservation rate was 96.8 per cent; there was no statistically significant difference between those with and without anterior commissure involvement (96.7 and 96.9 per cent respectively).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215116010021_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Transoral laser resection with the use of adjuvant radiotherapy in a minority of patients with adverse pathological findings can be recommended for the primary treatment of anterior commissure glottic cancer from an oncological perspective; excellent local control and laryngeal preservation rates can be achieved.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215116010021","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T09:59:05Z","timestamp":1484042345000},"page":"168-172","source":"Crossref","is-referenced-by-count":21,"title":["Transoral laser resection of glottic carcinoma: what is the significance of anterior commissure involvement?"],"prefix":"10.1017","volume":"131","author":[{"given":"K A","family":"Stephenson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"S0022215116010021_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20997"},{"key":"S0022215116010021_ref4","first-page":"503","article-title":"Intralaryngeal barriers to the spread of cancer","volume":"103","author":"Kirchner","year":"1987","journal-title":"Acta Otolaryngol"},{"key":"S0022215116010021_ref14","first-page":"57","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010"},{"key":"S0022215116010021_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24007"},{"key":"S0022215116010021_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2012.06138.x"},{"key":"S0022215116010021_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900409"},{"key":"S0022215116010021_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20993"},{"key":"S0022215116010021_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21278"},{"key":"S0022215116010021_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01994.x"},{"key":"S0022215116010021_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01944.x"},{"key":"S0022215116010021_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.10"},{"key":"S0022215116010021_ref2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/000348949610500412","article-title":"Carcinoma of the anterior commissure of the larynx: I. 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