{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:25:25Z","timestamp":1782789925572,"version":"3.54.5"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117000147_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000147_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000147_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (<jats:italic>p<\/jats:italic> &lt; 0.004) and diameters (<jats:italic>p<\/jats:italic> &lt; 0.004).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000147_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117000147","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T07:49:32Z","timestamp":1485416972000},"page":"221-226","source":"Crossref","is-referenced-by-count":5,"title":["Effects of agmatine sulphate on facial nerve injuries"],"prefix":"10.1017","volume":"131","author":[{"given":"O","family":"Surmelioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Tarkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dagkiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Surmelioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Polat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"S0022215117000147_ref20","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013860"},{"key":"S0022215117000147_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12996-7"},{"key":"S0022215117000147_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(83)90165-6"},{"key":"S0022215117000147_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90307-9"},{"key":"S0022215117000147_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00023"},{"key":"S0022215117000147_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90287-P"},{"key":"S0022215117000147_ref5","doi-asserted-by":"publisher","DOI":"10.3109\/02844318509074512"},{"key":"S0022215117000147_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00287-9"},{"key":"S0022215117000147_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200105000-00006"},{"key":"S0022215117000147_ref27","doi-asserted-by":"publisher","DOI":"10.3109\/10641969509087059"},{"key":"S0022215117000147_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10053"},{"key":"S0022215117000147_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.10310.x"},{"key":"S0022215117000147_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90016-0"},{"key":"S0022215117000147_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01625-6"},{"key":"S0022215117000147_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510401110"},{"key":"S0022215117000147_ref26","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1981.362.2.1331"},{"key":"S0022215117000147_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704153"},{"key":"S0022215117000147_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)02274-0"},{"key":"S0022215117000147_ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742201.x"},{"key":"S0022215117000147_ref16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.19.10584"},{"key":"S0022215117000147_ref25","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199105000-00017"},{"key":"S0022215117000147_ref18","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"S0022215117000147_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00229.x"},{"key":"S0022215117000147_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100088575"},{"key":"S0022215117000147_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)30966-6"},{"key":"S0022215117000147_ref6","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1523\/JNEUROSCI.15-05-03886.1995","article-title":"Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation","volume":"15","author":"Fu","year":"1995","journal-title":"J Neurosci"},{"key":"S0022215117000147_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10108"},{"key":"S0022215117000147_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.05.024"}],"container-title":["The Journal of Laryngology &amp; 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