{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T13:40:04Z","timestamp":1719063604426},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117000329_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to evaluate the oncological and voice outcomes of transoral laser microsurgery for tumour stage T<jats:sub>1b<\/jats:sub>stage glottic cancer patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000329_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A prospective cohort study in a tertiary care head and neck cancer centre included tumour\u2013node\u2013metastasis stage T<jats:sub>1b<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub>glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2002 until June 2014. Kaplan\u2013Meier five-year analyses of local control, overall survival, disease-specific survival and laryngeal preservation were performed. Voice Handicap Index-10 scores and maximum phonation times were also recorded.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000329_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Twenty-one participants with a mean age of 66.8 years were enrolled. The mean follow up was 56.5 months. Kaplan\u2013Meier 5-year survival analysis illustrated a local control rate of 82 per cent, overall survival of 88 per cent, disease-specific survival of 100 per cent, and laryngeal preservation of 100 per cent. The pre-operative Voice Handicap Index-10 score was 19.1 \u00b1 9.47 (mean \u00b1 standard deviation (SD)) and the post-operative scores were 13.5 \u00b1 9.29 at three months, 10.44 \u00b1 9.70 at one year and 5.83 \u00b1 4.91 at two years. The pre-operative maximum phonation time was 16.23 \u00b1 5.46 seconds (mean \u00b1 SD) and the post-operative values were 14.44 \u00b1 6.73 seconds at three months, 15.27 \u00b1 5.71 seconds at one year and 14.33 \u00b1 6.44 seconds at two years.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000329_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Transoral laser microsurgery yields relatively high rates of oncological control and acceptable voice outcomes, and thus shows utility as a primary treatment modality for T<jats:sub>1b<\/jats:sub>glottic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117000329","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T09:09:00Z","timestamp":1487063340000},"page":"433-441","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of transoral laser microsurgical management of T<sub>1b<\/sub>stage glottic cancer"],"prefix":"10.1017","volume":"131","author":[{"given":"J 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