{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:12:33Z","timestamp":1780387953504,"version":"3.54.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117000512_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To determine whether thiocolchicoside, a commonly used myorelaxant, may impair the acoustic reflex.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000512_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Forty-two patients scheduled to receive thiocolchicoside treatment for different reasons were enrolled in the study. Acoustic reflex thresholds at 500, 1000, 2000 and 4000 Hz were determined and analysed statistically pre-treatment and on the 5th day of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000512_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Increases were observed in the mean acoustic reflex thresholds on the 5th day of treatment compared to pre-treatment, at all frequencies, except right contralateral thresholds at 500 and 2000 Hz. These increases were statistically significant for right ipsilateral thresholds at 2000 and 4000 Hz, left ipsilateral thresholds at 500, 1000, 2000 and 4000 Hz, and left contralateral thresholds at 2000 and 4000 Hz (<jats:italic>p<\/jats:italic> \u2264 0.05), but not at other frequencies (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000512_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Muscle relaxant drugs, especially those affecting the central nervous system, may weaken the stapedial muscle so that the ability of noise to cause acoustic trauma may become evident. For this reason, physicians should advise their patients to avoid loud noises when muscle relaxant therapy is prescribed.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117000512","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T01:13:41Z","timestamp":1488417221000},"page":"497-500","source":"Crossref","is-referenced-by-count":3,"title":["Effects of thiocolchicoside, a commonly used myorelaxant, on the acoustic reflex"],"prefix":"10.1017","volume":"131","author":[{"given":"H H","family":"Arslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Cebeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Yildizoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Pusat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"S0022215117000512_ref17","first-page":"44","article-title":"Noise induced hearing loss and acoustic trauma [in Turkish]","volume":"6","author":"Kemalo\u011flu","year":"2013","journal-title":"Turkiye Klinikleri J ENT - Special Topics"},{"key":"S0022215117000512_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/00016486709139128"},{"key":"S0022215117000512_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-014-0739-x"},{"key":"S0022215117000512_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq312"},{"key":"S0022215117000512_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-200502000-00009"},{"key":"S0022215117000512_ref2","volume-title":"Diseases and Microsurgery of Ear","volume":"2","author":"Aky\u0131ld\u0131z","year":"1998"},{"key":"S0022215117000512_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790010035008"},{"key":"S0022215117000512_ref3","first-page":"79","article-title":"Effects of ethyl alcohol on acoustic reflex and trauma","volume":"15","author":"\u015eahin","year":"2010","journal-title":"F\u0131rat T\u0131p Dergisi"},{"key":"S0022215117000512_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20152"},{"key":"S0022215117000512_ref11","first-page":"121","article-title":"Effects of ethyl alcohol on the acoustic reflex threshold","volume":"2","author":"Cohill","year":"1977","journal-title":"J Am Audiol Soc"},{"key":"S0022215117000512_ref1","volume-title":"Diseases and Microsurgery of Ear","volume":"1","author":"Aky\u0131ld\u0131z","year":"1998"},{"key":"S0022215117000512_ref8","first-page":"159","article-title":"The effect of alcohol on the acoustic Reflex Relaxation Index","volume":"21","author":"Robinette","year":"1981","journal-title":"J Aud Res"},{"key":"S0022215117000512_ref14","first-page":"43","article-title":"Acoustic reflex and general anaesthesia","volume":"17","author":"Farkas","year":"1983","journal-title":"Scand Audiol Suppl"},{"key":"S0022215117000512_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.5.544"},{"key":"S0022215117000512_ref16","first-page":"416","article-title":"Stapedius reflex in curarized subjects: an index of neuromuscular weakness","volume":"52","author":"Ruth","year":"1982","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"S0022215117000512_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1975.tb05893.x"},{"key":"S0022215117000512_ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000275691"},{"key":"S0022215117000512_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470060404"},{"key":"S0022215117000512_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.11.002"},{"key":"S0022215117000512_ref6","first-page":"221","article-title":"Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions","volume":"13","author":"Janbroers","year":"1987","journal-title":"Acta Ther"}],"container-title":["The Journal of Laryngology &amp; 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