{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:46Z","timestamp":1760909086706},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117000573_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>This study aimed to evaluate serum cytokine concentrations in healthy individuals and laryngeal squamous cell carcinoma patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000573_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A total of 59 laryngeal squamous cell carcinoma patients and 44 healthy controls were included. Multiplex analysis of interleukins 2, 4, 5, 6, 10, 12, 13 and 17 and interferon-gamma with respect to the presence of laryngeal carcinoma, tumour\u2013node\u2013metastasis T stage, nodal involvement and larynx subsite was performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000573_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Statistical analysis revealed no difference in serum cytokine levels between patients and healthy controls. The serum interleukin-12 concentration was significantly higher in patients with early (T<jats:sub>1\u20132<\/jats:sub>) than in those with late (T<jats:sub>3\u20134<\/jats:sub>) stage disease and without nodal involvement (<jats:italic>p<\/jats:italic> &lt; 0.05). Serum interleukin-10 levels were significantly higher in T<jats:sub>3\u20134<\/jats:sub> stage than in T<jats:sub>1\u20132<\/jats:sub> stage patients (<jats:italic>p<\/jats:italic> &lt; 0.05). Additionally, serum interleukin 10, 12 and 13 concentrations (<jats:italic>p<\/jats:italic> &lt; 0.05) and interleukin-6 concentration (<jats:italic>p<\/jats:italic> &lt; 0.01) were significantly higher in patients with T<jats:sub>1\u20132<\/jats:sub> stage supraglottic <jats:italic>vs<\/jats:italic> glottic tumours.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000573_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Serum cytokines level cannot be used as laryngeal squamous cell carcinoma markers. Progression from T<jats:sub>1\u20132<\/jats:sub> to T<jats:sub>3\u20134<\/jats:sub> stage is followed by decreased serum interleukin-12 levels and increased interleukin-10 levels. Nodal involvement is associated with lower serum interleukin-12 levels. In patients with early stage tumours, serum interleukin 6, 10, 12 and 13 concentrations are significantly higher in those with supraglottic <jats:italic>vs<\/jats:italic> glottic tumours.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117000573","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T06:07:53Z","timestamp":1489558073000},"page":"455-461","source":"Crossref","is-referenced-by-count":10,"title":["Serum cytokine profile of laryngeal squamous cell carcinoma 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