{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:49:14Z","timestamp":1774010954923,"version":"3.50.1"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117000627_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>This paper reports three cases of severe post-stapedectomy granuloma, emphasising the variable presentation of this devastating complication and the challenges of its management.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000627_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective review was conducted of three cases of post-stapedectomy granuloma requiring surgical debulking between 2010 and 2015. Clinical symptoms, serial imaging, histopathology and post-operative outcomes were considered.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000627_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Intra-operatively, extensive granulation tissue with erosion of the otic capsule was found. There was spread along the VIIth and VIIIth cranial nerves to the cochlear nucleus in one patient. Post-operative clinical improvement was demonstrable, corroborated by diminution of contrast enhancement on serial magnetic resonance imaging. Facial nerve function recovered, tinnitus amelioration was variable and some otalgia persisted. Post-operative complications included grade IV facial weakness and late<jats:italic>Pseudomonas aeruginosa<\/jats:italic>meningitis, which all resolved.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117000627_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>To the authors\u2019 knowledge, this paper reports the only case of post-stapedectomy granuloma tracking to the brainstem. Otalgia was present in all our cases, and may be deemed a red flag symptom of progressive bony destruction and otic capsule involvement. Although granuloma remains rare, it should be considered in any patient with worsening otological symptoms following stapes surgery.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117000627","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T02:41:25Z","timestamp":1489977685000},"page":"557-560","source":"Crossref","is-referenced-by-count":6,"title":["Post-stapedectomy granuloma: a devastating complication"],"prefix":"10.1017","volume":"131","author":[{"given":"E","family":"Watts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H R F","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"S0022215117000627_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900516"},{"key":"S0022215117000627_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510007701X"},{"key":"S0022215117000627_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600511"},{"key":"S0022215117000627_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1974.00780040179003"},{"key":"S0022215117000627_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196207000-00003"},{"key":"S0022215117000627_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-007-0098-y"},{"key":"S0022215117000627_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100133134"},{"key":"S0022215117000627_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/000348945806700403"},{"key":"S0022215117000627_ref1","first-page":"275","article-title":"Complications of stapedectomies","volume":"4","author":"Causse","year":"1983","journal-title":"Am J Otol"},{"key":"S0022215117000627_ref8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0030-6665(20)30822-7","article-title":"Complications in stapes surgery: options for prevention and management","volume":"26","author":"Wiet","year":"1993","journal-title":"Otolaryngol Clin North Am"},{"key":"S0022215117000627_ref2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199509000-00005"},{"key":"S0022215117000627_ref4","first-page":"155","article-title":"Update of reparative granuloma: survey of the American Otological Society and the American Neurotology Society","volume":"15","author":"Seicshnaydre","year":"1994","journal-title":"Am J Otol"},{"key":"S0022215117000627_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(01)00106-7"},{"key":"S0022215117000627_ref14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0030-6665(20)30821-5","article-title":"Stapedectomy: causes of failure and revision surgery in otosclerosis","volume":"26","author":"Hough","year":"1993","journal-title":"Otolaryngol Clin North Am"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215117000627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T03:40:41Z","timestamp":1601782841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215117000627\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0022215117000627"],"URL":"https:\/\/doi.org\/10.1017\/s0022215117000627","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,20]]}}}