{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:47Z","timestamp":1792088027011,"version":"4.4.0"},"reference-count":76,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001001_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001001_sec_a2\"><jats:title>Study design:<\/jats:title><jats:p>Literature review.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001001_sec_a3\"><jats:title>Methods:<\/jats:title><jats:p>The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001001_sec_a4\"><jats:title>Results:<\/jats:title><jats:p>A total of 76 studies were included in the analysis. Topical applications of certain agents (e.g. growth factors, Ofloxacin Otic Solution, and insulin solutions) to the moist edges of traumatic tympanic membrane perforations shortened closure times and improved closure rates.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001001_sec_a5\"><jats:title>Conclusion:<\/jats:title><jats:p>Dry tympanic membrane perforation edges may be associated with crust formation and centrifugal migration, delaying perforation closure. On the contrary, moist edges inhibit necrosis at the perforation margins, stimulate proliferation of granulation tissue and aid eardrum healing. Thus, moist perforation margins upon topical application of solutions of appropriate agents aid the regeneration of traumatic tympanic membrane perforations.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001001","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T02:01:42Z","timestamp":1494813702000},"page":"564-571","source":"Crossref","is-referenced-by-count":24,"title":["A moist edge environment aids the regeneration of traumatic tympanic membrane perforations"],"prefix":"10.1017","volume":"131","author":[{"given":"Z C","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z H","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"S0022215117001001_ref74","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208000-00027"},{"key":"S0022215117001001_ref65","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100131986"},{"key":"S0022215117001001_ref38","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.Sup3.15546"},{"key":"S0022215117001001_ref76","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(82)90074-X"},{"key":"S0022215117001001_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.12.006"},{"key":"S0022215117001001_ref22","article-title":"Study of myringoplasty in wet and dry ears in mucosal type of chronic otitis media","volume":"10","author":"Santosh","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"S0022215117001001_ref60","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812456813"},{"key":"S0022215117001001_ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-009-1403-2"},{"key":"S0022215117001001_ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2689-4"},{"key":"S0022215117001001_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2014.05.014"},{"key":"S0022215117001001_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00371-3"},{"key":"S0022215117001001_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464402"},{"key":"S0022215117001001_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01764.x"},{"key":"S0022215117001001_ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.01.022"},{"key":"S0022215117001001_ref55","first-page":"802","article-title":"Cytology of repair in experimental perforation of the tympanic membrane and its relationship to chronic perforations in man","volume":"71","author":"Taylor","year":"1967","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"S0022215117001001_ref27","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198407000-00011"},{"key":"S0022215117001001_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3859-3"},{"key":"S0022215117001001_ref46","doi-asserted-by":"publisher","DOI":"10.1163\/1568562054255709"},{"key":"S0022215117001001_ref47","doi-asserted-by":"publisher","DOI":"10.1159\/000343775"},{"key":"S0022215117001001_ref69","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12627"},{"key":"S0022215117001001_ref72","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610013439"},{"key":"S0022215117001001_ref30","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.4.5.529"},{"key":"S0022215117001001_ref71","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600678797"},{"key":"S0022215117001001_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00947.x"},{"key":"S0022215117001001_ref2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2001.11445496"},{"key":"S0022215117001001_ref43","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200009010-00012"},{"key":"S0022215117001001_ref73","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1953.00710040427003"},{"key":"S0022215117001001_ref44","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199505000-00007"},{"key":"S0022215117001001_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25300"},{"key":"S0022215117001001_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001080"},{"key":"S0022215117001001_ref5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0030-6665(20)30467-9","article-title":"Tympanic membrane wound healing. 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