{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T19:11:21Z","timestamp":1724958681453},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001116_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the inflammatory\/anti-inflammatory cytokine balance \u2013 T helper 1\/T helper 2 ratios \u2013 in obstructive sleep apnoea patients, before and after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001116_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>Twenty-eight patients received continuous positive airway pressure treatment and 29 patients who could not tolerate continuous positive airway pressure were scheduled for surgery. Serum levels of interleukins 2, 4 and 10, tumour necrosis factor-alpha, and interferon gamma were analysed by enzyme-linked immunosorbent assays before and three months after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001116_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>The success rate of surgical treatment was 65.5 per cent. Mean compliance for the continuous positive airway pressure group was 40.9 per cent. The apnoea\/hypopnoea index significantly decreased in both groups after treatment (<jats:italic>p<\/jats:italic>&lt; 0.001). The interferon gamma\/interleukin-4 ratio decreased following surgical treatment (<jats:italic>p<\/jats:italic>= 0.014), and the interleukin-2\/interleukin-4 ratio decreased after treatment in 57 patients in the overall cohort (<jats:italic>p<\/jats:italic>= 0.032).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001116_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>After treatment for obstructive sleep apnoea, some ratios reflecting T helper 1\/T helper 2 cytokine balance favoured the T helper 2 direction, suggesting a shift to an anti-inflammatory state. Successful surgery and better continuous positive airway pressure compliance can help ameliorate inflammation in obstructive sleep apnoea patients, which may reduce associated morbidities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001116","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T10:23:24Z","timestamp":1495535004000},"page":"719-727","source":"Crossref","is-referenced-by-count":5,"title":["Effect of modern surgical treatment on the inflammatory\/anti-inflammatory balance in patients with obstructive sleep apnoea"],"prefix":"10.1017","volume":"131","author":[{"given":"M","family":"Binar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"Akcam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Karakoc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R I","family":"Sagkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Musabak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gerek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"S0022215117001116_ref25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. 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