{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:19:56Z","timestamp":1792678796533,"version":"4.5.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001153_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To identify deep neck infection factors related to life-threatening complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001153_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>This retrospective multi-institutional study comprised 586 patients treated for deep neck infections between 2002 and 2012. The statistical significance of variables associated with life-threatening complications of deep neck infections was assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001153_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>During treatment, life-threatening complications occurred in 60 out of 586 cases. On univariate analysis, life-threatening complications were linked to: dyspnoea, neck movement disturbance and dysphonia (all <jats:italic>p<\/jats:italic> &lt; 0.001); and parapharyngeal, anterior visceral or pretracheal deep neck involvement (all <jats:italic>p<\/jats:italic> &lt; 0.002). Aetiology was significantly linked to tonsils (<jats:italic>p<\/jats:italic> &lt; 0.001). Regarding infection type, fasciitis was a significant factor (<jats:italic>p<\/jats:italic> &lt; 0.001). <jats:italic>Candida albicans<\/jats:italic> was a significant bacterial culture (<jats:italic>p<\/jats:italic> &lt; 0.001). A multivariate step-wise model disclosed fewer significant variables: retropharyngeal space (<jats:italic>p<\/jats:italic> = 0.005) and major blood vessels area (<jats:italic>p<\/jats:italic> = 0.006) involvement, and bacterial culture <jats:italic>C albicans<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001153_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>It can be predicted that patients with deep neck infections, with neck movement disturbances, dysphonia, dyspnoea and swelling of the external neck, accompanied by severe pain, and inflammatory changes in the retropharyngeal space and large vessel areas, with culture-confirmed infection of <jats:italic>C albicans<\/jats:italic>, are likely to develop life-threatening complications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001153","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T02:22:37Z","timestamp":1496629357000},"page":"779-784","source":"Crossref","is-referenced-by-count":26,"title":["Univariate and multivariate models for the prediction of life-threatening complications in 586 cases of deep neck space infections: retrospective multi-institutional study"],"prefix":"10.1017","volume":"131","author":[{"given":"J","family":"Mejzlik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Celakovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Tucek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kotulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Vrbacky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Matousek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Stanikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hoskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pazs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mittu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Chrobok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"S0022215117001153_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23776"},{"key":"S0022215117001153_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0284185113509093"},{"key":"S0022215117001153_ref5","first-page":"335","article-title":"Predisposing factors of complicated deep neck infections: 12-year experience at a single institution","volume":"39","author":"Wang","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215117001153_ref4","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2014.7.2.133"},{"key":"S0022215117001153_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500395195"},{"key":"S0022215117001153_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1761-1"},{"key":"S0022215117001153_ref12","first-page":"45","article-title":"Pitfalls of CT for deep neck abscess imaging assessment: a retrospective review of 162 cases","volume":"9","author":"Chuang","year":"2013","journal-title":"B-ENT"},{"key":"S0022215117001153_ref2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/0310057X0903700411","article-title":"A retrospective analysis of deep neck infections at Royal Perth Hospital","volume":"37","author":"Matzelle","year":"2009","journal-title":"Anaesth Intensive Care"},{"key":"S0022215117001153_ref13","first-page":"2061","article-title":"Multivariate approach to investigating prognostic factors in deep neck infections","volume":"271","author":"Staffieri","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215117001153_ref3","first-page":"136","article-title":"An atypical deep neck infection in a two-year-old child","volume":"22","author":"Raffaldi","year":"2014","journal-title":"Infez Med"},{"key":"S0022215117001153_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.06.001"},{"key":"S0022215117001153_ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2012.06.008"},{"key":"S0022215117001153_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.05.007"}],"container-title":["The Journal of Laryngology &amp; 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