{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:57:44Z","timestamp":1772132264145,"version":"3.50.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001244_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001244_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001244_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>A total of 188 patients fit the inclusion criteria. Of these, 125 (66 per cent) underwent thyroidectomy. The thyroid was involved in 10 of the 125 patients (8 per cent), 9 by direct extension and 1 by metastasis. Cartilage invasion was a predictor of thyroid gland involvement, with a positive predictive value of 26 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001244_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>There is a low incidence of thyroid gland involvement in laryngeal carcinoma. Most cases of gland involvement occurred by direct extension. Thyroidectomy during laryngectomy should be considered for advanced stage tumours with cartilage invasion.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001244","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T07:59:34Z","timestamp":1496908774000},"page":"740-744","source":"Crossref","is-referenced-by-count":15,"title":["Management of the thyroid gland during laryngectomy"],"prefix":"10.1017","volume":"131","author":[{"given":"S X","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Polacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L X","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Titus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Paydarfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"S0022215117001244_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000165454.75480.EA"},{"key":"S0022215117001244_ref11","article-title":"Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx","author":"Mangussi-Gomes","year":"2016","journal-title":"Braz J Otorhinolaryngol"},{"key":"S0022215117001244_ref2","first-page":"1207","article-title":"Laryngectomy for carcinoma of the larynx","volume":"11","author":"Jackson","year":"1931","journal-title":"Surg Clin North Am"},{"key":"S0022215117001244_ref17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-199109000-00003","article-title":"The intraoperative management of the thyroid gland during laryngectomy","volume":"101","author":"Brennan","year":"2001","journal-title":"Laryngoscope"},{"key":"S0022215117001244_ref1","first-page":"210","article-title":"Total laryngectomy \u2013 past, present, future","volume":"9","author":"Ceachir","year":"2014","journal-title":"Maedica (Buchar)"},{"key":"S0022215117001244_ref4","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2001.20211"},{"key":"S0022215117001244_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21972"},{"key":"S0022215117001244_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12165"},{"key":"S0022215117001244_ref10","first-page":"5","article-title":"Thyroid gland involvement in carcinoma larynx and hypopharynx--predictive factors and prognostic significance","volume":"10","author":"Iype","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"S0022215117001244_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3828-x"},{"key":"S0022215117001244_ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1997.00835.x"},{"key":"S0022215117001244_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.07.003"},{"key":"S0022215117001244_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.03.450"},{"key":"S0022215117001244_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.5.652"},{"key":"S0022215117001244_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.02.006"},{"key":"S0022215117001244_ref14","first-page":"564","article-title":"Routine thyroidectomy in total laryngectomy: is it really indicated?","volume":"38","author":"Al-Khatib","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215117001244_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25263"},{"key":"S0022215117001244_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2011.04.002"},{"key":"S0022215117001244_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25417"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215117001244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:18:48Z","timestamp":1750295928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215117001244\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0022215117001244"],"URL":"https:\/\/doi.org\/10.1017\/s0022215117001244","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,8]]}}}