{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:38:59Z","timestamp":1793882339515,"version":"4.7.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001281_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>Tuberculosis is a global health problem that is especially prevalent in developing countries such as India. Recently, atypical presentation has become more common and a high index of suspicion is essential. This study analysed the various presenting symptoms and signs of tuberculous otitis media and the role of diagnostic tests, with the aim of formulating criteria for the diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001281_sec_a2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>A total of 502 patients underwent tympanomastoidectomy over a two-year period. Microbiological and histopathological examinations and polymerase chain reaction analysis of tissue taken during tympanomastoidectomy were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001281_sec_a3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>A total of 25 patients (5 per cent) were diagnosed with tuberculous otitis media. Severe mixed hearing loss, facial palsy, labyrinthine fistula, post-aural fistula, perichondritis and extradural abscess were noted.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001281_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>There seems to be a resurgence in tuberculous otitis media in India. Microbiological, histopathological and polymerase chain reaction tests for tuberculosis are helpful for its diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001281","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T06:05:14Z","timestamp":1500530714000},"page":"785-792","source":"Crossref","is-referenced-by-count":28,"title":["Tuberculous otitis media: a resurgence?"],"prefix":"10.1017","volume":"131","author":[{"given":"M","family":"Kameswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Parthiban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P V","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Raghunandhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"S0022215117001281_ref3","first-page":"331","article-title":"Aural tuberculosis in children","volume":"66","author":"Birrel","year":"1973","journal-title":"Proc R Soc Med"},{"key":"S0022215117001281_ref16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5858\/2003-127-0326-COPCRW","article-title":"Comparison of polymerase chain reaction with histopathological features for diagnosis of tuberculosis","volume":"127","author":"Do","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"S0022215117001281_ref12","first-page":"160","article-title":"Tuberculosis of the middle ear with postauricular abscess","volume":"56","author":"Arya","year":"2009","journal-title":"Indian J Tuberc"},{"key":"S0022215117001281_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100076878"},{"key":"S0022215117001281_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100036203"},{"key":"S0022215117001281_ref2","first-page":"167","volume-title":"Surgery of the ear","author":"Slattery","year":"1990"},{"key":"S0022215117001281_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2012.06.005"},{"key":"S0022215117001281_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(12)80257-4"},{"key":"S0022215117001281_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-7-5"},{"key":"S0022215117001281_ref4","first-page":"1530","volume-title":"Otologic surgery","author":"Burns","year":"1991"},{"key":"S0022215117001281_ref1","first-page":"1","volume-title":"Scott Brown's Otolaryngology","author":"Mills","year":"1997"},{"key":"S0022215117001281_ref5","first-page":"3088","article-title":"Systemic disease manifestations in the middle ear and temporal bone","volume":"3","author":"Nadol","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215117001281_ref8","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195311000-00003"},{"key":"S0022215117001281_ref11","first-page":"65","volume-title":"ENT disorders in a tropical environment","author":"Grewal","year":"1999"},{"key":"S0022215117001281_ref17","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00181"},{"key":"S0022215117001281_ref13","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.2999980","article-title":"Enzymatic amplification of beta globulin genome sequences and restriction site analyses for diagnosis of sickle cell anemia","volume":"230","author":"Mullis","year":"1985","journal-title":"Science"},{"key":"S0022215117001281_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100090265"},{"key":"S0022215117001281_ref14","first-page":"55","article-title":"Tuberculosis of the middle ear \u2013 a case report","volume":"42","author":"Mahajan","year":"1995","journal-title":"Indian J Tuberc"},{"key":"S0022215117001281_ref15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/JCM.30.1.255-258.1992","article-title":"Use of polymerase chain reaction for rapid diagnosis of tuberculosis","volume":"30","author":"Cousins","year":"1992","journal-title":"J Clin Microbiol"}],"container-title":["The Journal of Laryngology &amp; 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