{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:41:27Z","timestamp":1793925687793,"version":"4.8.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001335_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the role of local allergic inflammation and <jats:italic>Staphylococcus aureus<\/jats:italic> enterotoxins in chronic rhinosinusitis with nasal polyps.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001335_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>This study included 36 patients with chronic rhinosinusitis with nasal polyps and 18 controls. Total immunoglobulin E, eosinophil cationic protein, staphylococcal enterotoxin types A and B specific immunoglobulin E, staphylococcal enterotoxin types A and B, and myeloperoxidase levels were determined.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001335_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Four patients with chronic rhinosinusitis with nasal polyps had a local allergy. All chronic rhinosinusitis with nasal polyps patients tested negative for staphylococcal enterotoxin types A and B specific immunoglobulin E. The chronic rhinosinusitis with nasal polyps group had significantly elevated staphylococcal enterotoxin types A and B levels in the supernatant. Fourteen patients belonged to the eosinophilic chronic rhinosinusitis with nasal polyps group and the others were characterised as having non-eosinophilic chronic rhinosinusitis with nasal polyps.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001335_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Local allergy may play a role in chronic rhinosinusitis with nasal polyps, independent of staphylococcal enterotoxin superantigens. Staphylococcal enterotoxins may be important in the pathogenesis of chronic rhinosinusitis with nasal polyps; however, their roles as superantigens were not confirmed in this study. In Chinese subjects, chronic rhinosinusitis with nasal polyps usually manifests as a neutrophilic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001335","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T06:54:32Z","timestamp":1499410472000},"page":"707-713","source":"Crossref","is-referenced-by-count":16,"title":["Role of local allergic inflammation and <i>Staphylococcus aureus<\/i> enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1017","volume":"131","author":[{"given":"K-J","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-Y","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-L","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-H","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-Q","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"S0022215117001335_ref22","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2887"},{"key":"S0022215117001335_ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. 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