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The short- and long-term outcomes of collagen matrix in skull base reconstruction are described.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001499_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A case series of patients who underwent endoscopic skull base reconstruction with collagen matrix inlay were assessed. Immediate peri-operative outcomes (cerebrospinal fluid leak, meningitis, ventriculitis, intracranial bleeding, epistaxis, seizures) and delayed complications (delayed healing, meningoencephalocele, prolapse of reconstruction, delayed cerebrospinal fluid leak, ascending meningitis) were examined.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001499_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Of 120 patients (51.0 \u00b1 17.5 years, 41.7 per cent female), peri-operative complications totalled 12.7 per cent (cerebrospinal fluid leak, 3.3 per cent; meningitis, 3.3 per cent; other intracranial infections, 2.5 per cent; intracranial bleeding, 1.7 per cent; epistaxis, 1.7 per cent; and seizures, 0 per cent). Delayed complications did not occur in any patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001499_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Collagen matrix is an effective inlay material. 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