{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T15:19:36Z","timestamp":1703085576946},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001657_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001657_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001657_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (<jats:italic>p<\/jats:italic>&lt; 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (<jats:italic>p<\/jats:italic>&lt; 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second\/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001657_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001657","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T08:50:44Z","timestamp":1502787044000},"page":"880-888","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps"],"prefix":"10.1017","volume":"131","author":[{"given":"Q L","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L L","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X X","family":"Zi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y Y","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H P","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"S0022215117001657_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154"},{"key":"S0022215117001657_ref9","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.4.232"},{"key":"S0022215117001657_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"S0022215117001657_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21628"},{"key":"S0022215117001657_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.047"},{"key":"S0022215117001657_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-118"},{"key":"S0022215117001657_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-8-85"},{"key":"S0022215117001657_ref19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4193\/Rhino10.261","article-title":"Mucosal eosinophilia and recurrence of nasal polyps \u2013 new classification of chronic rhinosinusitis","volume":"49","author":"Nakayama","year":"2011","journal-title":"Rhinology"},{"key":"S0022215117001657_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21674"},{"key":"S0022215117001657_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.03.033"},{"key":"S0022215117001657_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114000450"},{"key":"S0022215117001657_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21631"},{"key":"S0022215117001657_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03484.x"},{"key":"S0022215117001657_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.036"},{"key":"S0022215117001657_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02811.x"},{"key":"S0022215117001657_ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000126066"},{"key":"S0022215117001657_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-015-0100-2"},{"key":"S0022215117001657_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21370"},{"key":"S0022215117001657_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"S0022215117001657_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23246"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215117001657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T05:44:43Z","timestamp":1659332683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215117001657\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0022215117001657"],"URL":"https:\/\/doi.org\/10.1017\/s0022215117001657","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]}}}