{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:50:33Z","timestamp":1776700233597,"version":"3.51.2"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001669_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>To determine the locoregional control and survival rates (in terms of risk factors) of patients who underwent surgical resection of early-stage lip cancer and for whom a \u2018wait and see\u2019 policy in terms of neck status had been implemented.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001669_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>The sociodemographic data, tumour stage, tumour characteristics and histopathological features of 41 patients with early-stage lip cancer were evaluated. Factors predictive of survival and locoregional recurrence were analysed. The five-year overall survival and disease-free survival rates were determined, and the prognostic risk factors were compared.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001669_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>The mean follow-up period was 60.5 months (range, 4\u201392 months). Age, sex, tumour stage, tumour thickness and volume, and perineural involvement were not predictive of locoregional recurrence or survival. Pathological tumour stage (T<jats:sub>1<\/jats:sub><jats:italic>vs<\/jats:italic>T<jats:sub>2<\/jats:sub>) was a prognostic factor for both five-year overall survival (87.3<jats:italic>vs<\/jats:italic>65.6 per cent,<jats:italic>p<\/jats:italic>= 0.042) and disease-free survival (88.6<jats:italic>vs<\/jats:italic>65.6 per cent,<jats:italic>p<\/jats:italic>= 0.037).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001669_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Tumour stage was clearly a major factor affecting the prognosis of surgically treated patients with early-stage lip cancer for whom a \u2018wait and see\u2019 policy in terms of neck status had been implemented.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001669","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T08:50:27Z","timestamp":1502787027000},"page":"889-894","source":"Crossref","is-referenced-by-count":9,"title":["Stage is a prognostic factor for surgically treated patients with early-stage lip cancer for whom a \u2018wait and see\u2019 policy in terms of neck status has been implemented"],"prefix":"10.1017","volume":"131","author":[{"given":"G","family":"Eskiizmir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ozgur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Temiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Hacioglu","family":"Yanar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Cengiz","family":"Ozyurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"S0022215117001669_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70050-1"},{"key":"S0022215117001669_ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"S0022215117001669_ref20","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19595"},{"key":"S0022215117001669_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.09.020"},{"key":"S0022215117001669_ref11","unstructured":"Head and Neck Cancers NCCN Guidelines. In: https:\/\/www.pdf-archive.com\/2015\/08\/30\/head-and-neck\/head-and-neck.pdf [20 September 2016]"},{"key":"S0022215117001669_ref9","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20965"},{"key":"S0022215117001669_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2003.08.007"},{"key":"S0022215117001669_ref4","first-page":"992","article-title":"Lip cancer experience in Mexico","volume":"40","author":"Luna-Ortiz","year":"2004","journal-title":"An 11-year retrospective study. Oral Oncol"},{"key":"S0022215117001669_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.03.054"},{"key":"S0022215117001669_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70010-4"},{"key":"S0022215117001669_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90006-T"},{"key":"S0022215117001669_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09698.x"},{"key":"S0022215117001669_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70162-8"},{"key":"S0022215117001669_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0b013e31811ec221"},{"key":"S0022215117001669_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21022"},{"key":"S0022215117001669_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24161"},{"key":"S0022215117001669_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12586"},{"key":"S0022215117001669_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01105.x"},{"key":"S0022215117001669_ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0030-6665(20)30844-6","article-title":"Carcinoma of the lip","volume":"26","author":"Zitsch","year":"1993","journal-title":"Otolaryngol Clin North Am"},{"key":"S0022215117001669_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00141-6"},{"key":"S0022215117001669_ref10","volume-title":"Jatin Shah's Head and Neck Surgery and Oncology","author":"Shah","year":"2012"},{"key":"S0022215117001669_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0742-z"},{"key":"S0022215117001669_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23772"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215117001669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T07:16:38Z","timestamp":1602746198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215117001669\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0022215117001669"],"URL":"https:\/\/doi.org\/10.1017\/s0022215117001669","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]}}}