{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:43:44Z","timestamp":1772491424259,"version":"3.50.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001797_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001797_sec_a2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001797_sec_a3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (<jats:italic>p<\/jats:italic> = 0.69) or post-operative serum parathyroid hormone (<jats:italic>p<\/jats:italic> = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (<jats:italic>p<\/jats:italic> = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (<jats:italic>p<\/jats:italic> = 0.032).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001797_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001797","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T03:03:37Z","timestamp":1504667017000},"page":"925-929","source":"Crossref","is-referenced-by-count":5,"title":["Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 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