{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:28:26Z","timestamp":1786624106340,"version":"build-2736575974"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215117001840_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>Acute mastoiditis remains the commonest intratemporal complication of otitis media in the paediatric population. There has been a lack of consensus regarding the diagnosis and management of acute mastoiditis, resulting in considerable disparity in conservative and surgical management.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001840_sec_a2\"><jats:title>Objectives:<\/jats:title><jats:p>To review the current literature, proposing recommendations for the management of paediatric acute mastoiditis and appraising the treatment outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001840_sec_a3\" sec-type=\"methods\"><jats:title>Method:<\/jats:title><jats:p>A systematic review was conducted using PubMed, Web of Science and Cochrane Library databases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001840_sec_a4\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Twenty-one studies were included, with a total of 564 patients. Cure rates of medical treatment, conservative surgery and mastoidectomy were 95.9 per cent, 96.3 per cent and 89.1 per cent, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215117001840_sec_a5\" sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>Mastoidectomy may be the most definitive treatment available; however, reviewed data suggest that conservative treatment alone has high efficacy as first-line treatment in uncomplicated cases of acute mastoiditis, and conservative therapy may be an appropriate first-line management when treating acute mastoiditis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215117001840","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T10:01:39Z","timestamp":1504778499000},"page":"96-104","source":"Crossref","is-referenced-by-count":85,"title":["Management of paediatric acute mastoiditis: systematic review"],"prefix":"10.1017","volume":"132","author":[{"given":"R","family":"Loh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Phua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-K L","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"S0022215117001840_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(87)80042-X"},{"key":"S0022215117001840_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)01118-H"},{"key":"S0022215117001840_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.06.022"},{"key":"S0022215117001840_ref37","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181de24bc"},{"key":"S0022215117001840_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.05.002"},{"key":"S0022215117001840_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-10-1"},{"key":"S0022215117001840_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112002332"},{"key":"S0022215117001840_ref36","first-page":"478","article-title":"Workshop 3\u2013source of bias in case series, patient cohorts, and randomised controlled trials","volume":"17","author":"Yu","year":"2011","journal-title":"Hong Kong Med J"},{"key":"S0022215117001840_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.12.002"},{"key":"S0022215117001840_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00406-7"},{"key":"S0022215117001840_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki257"},{"key":"S0022215117001840_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200102000-00004"},{"key":"S0022215117001840_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957692"},{"key":"S0022215117001840_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31817f736b"},{"key":"S0022215117001840_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00626-7"},{"key":"S0022215117001840_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.09.032"},{"key":"S0022215117001840_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-015-0479-4"},{"key":"S0022215117001840_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890140023006"},{"key":"S0022215117001840_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22193"},{"key":"S0022215117001840_ref16","doi-asserted-by":"publisher","DOI":"10.7874\/kja.2013.17.2.97"},{"key":"S0022215117001840_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.29"},{"key":"S0022215117001840_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70347-4"},{"key":"S0022215117001840_ref20","first-page":"123","article-title":"One to make the diagnosis. 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