{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:48:54Z","timestamp":1780476534472,"version":"3.54.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118000221_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>The relationship between hypertension and epistaxis is controversial and poorly understood. The present research investigated atherosclerosis as a potential risk factor in hypertensive patients with epistaxis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000221_sec_a2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>A prospective study of 141 hypertensive patients with epistaxis was conducted. The laboratory tests included full blood count, lipid profile and coagulation profile. All patients underwent funduscopic examination of the eye and were classified in terms of four retinopathy grades.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000221_sec_a3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>There were strong positive correlations between the number of nosebleeds and retinopathy grade and low-density lipoprotein cholesterol level. There were weak correlations between the number of nosebleeds and blood pressure readings and triglycerides levels. Patients with grade III retinopathy, suggesting atherosclerosis, suffered from more frequent nosebleeds than other patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000221_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>Atherosclerosis is one of the potential risk factors in hypertensive patients with epistaxis. This may have an impact on treatment choices.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118000221","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T03:58:15Z","timestamp":1518667095000},"page":"323-326","source":"Crossref","is-referenced-by-count":10,"title":["The significance of atherosclerosis in hypertensive patients with epistaxis"],"prefix":"10.1017","volume":"132","author":[{"given":"S","family":"Elwany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bazak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"S0022215118000221_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000090122.38230.41"},{"key":"S0022215118000221_ref21","first-page":"329","article-title":"The relation of systemic hypertension to changes in the retinal vasculature","volume":"95","author":"Klein","year":"1997","journal-title":"The Beaver Dam Eye Study. 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