{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:37:14Z","timestamp":1766137034267},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"unspecified","delay-in-days":1,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118000452_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Trimethoprim\/sulfamethoxazole has been suggested as a treatment option for chronic rhinosinusitis with purulence. This study aimed to assess the functional and endoscopic outcomes after a three-month course of low-dose trimethoprim\/sulfamethoxazole.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000452_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A prospective study was performed, comprising patients referred to a tertiary care medical centre with a diagnosis of chronic rhinosinusitis with purulence. Trimethoprim\/sulfamethoxazole was prescribed at 960 mg\/day for three months. Sinonasal complaints and endoscopic findings were documented, and bacteriological data were compared.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000452_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Fifteen patients were included.<jats:italic>Staphylococcus aureus<\/jats:italic>was the most common bacterium cultured (86 per cent). Improvement in nasal function, as measured by the 22-item Sino-Nasal Outcome Test, was highly significant at three months (<jats:italic>p<\/jats:italic>&lt; 0.0005). This improvement slightly decreased but remained significant at 6, 9 and 12 months. No side effects were noted. Endoscopic scores revealed similar and concordant improvements.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000452_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Long-term low-dose trimethoprim\/sulfamethoxazole therapy seems to be a safe option for selected patients. Additional randomised multicentre studies remain necessary.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118000452","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T05:38:43Z","timestamp":1530509923000},"page":"600-604","source":"Crossref","is-referenced-by-count":3,"title":["Functional outcome after long-term low-dose trimethoprim\/sulfamethoxazole in chronic rhinosinusitis with purulence: a prospective study"],"prefix":"10.1017","volume":"132","author":[{"given":"G","family":"de Bonnecaze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Chaput","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dupret-Bories","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Vergez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"S0022215118000452_ref7","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1022"},{"key":"S0022215118000452_ref1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"3","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"S0022215118000452_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-014-0048-6"},{"key":"S0022215118000452_ref3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4193\/Rhino11.123","article-title":"Long-term low-dose antibiotics in recalcitrant chronic rhinosinusitis: a retrospective analysis","volume":"50","author":"Videler","year":"2012","journal-title":"Rhinology"},{"key":"S0022215118000452_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0416-2"},{"key":"S0022215118000452_ref13","first-page":"73","article-title":"Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis","volume":"525","author":"Hashiba","year":"1996","journal-title":"Acta Otolaryngol Suppl"},{"key":"S0022215118000452_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.020"},{"key":"S0022215118000452_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.006"},{"key":"S0022215118000452_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000124936.46948.6a"},{"key":"S0022215118000452_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12315"},{"key":"S0022215118000452_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(03)00103-6"},{"key":"S0022215118000452_ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.124849"},{"key":"S0022215118000452_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00008"},{"key":"S0022215118000452_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812470427"},{"key":"S0022215118000452_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000191560.53555.08"},{"key":"S0022215118000452_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02693.x"},{"key":"S0022215118000452_ref17","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin13.074"},{"key":"S0022215118000452_ref20","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117410"},{"key":"S0022215118000452_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12040"},{"key":"S0022215118000452_ref5","first-page":"CD008233","article-title":"Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults","volume":"5","author":"Piromchai","year":"2011","journal-title":"Cochrane Database Syst Rev"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215118000452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T20:45:11Z","timestamp":1661546711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215118000452\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0022215118000452"],"URL":"https:\/\/doi.org\/10.1017\/s0022215118000452","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}