{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:20:34Z","timestamp":1794442834185,"version":"4.9.1"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"unspecified","delay-in-days":42,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118000555_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>Advanced hypopharyngeal carcinoma has a dismal prognosis. The optimal treatment for these patients remains under debate. This systematic review aimed to compare survival following surgical and non-surgical treatments.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000555_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>A systematic review was conducted of randomised studies, with a descriptive analysis of retrospective observational studies.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000555_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>Two randomised trials and 11 observational studies were included in the review. A meta-analysis of randomised trials reported a hazard ratio of 0.89 for overall survival in favour of surgical treatment (<jats:italic>p<\/jats:italic> = 0.44). Neither treatment was favoured in terms of overall survival. Observational studies did not report a survival advantage with either treatment. The five-year larynx preservation rates for non-surgically treated patients were between 38 and 58 percent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000555_sec_a4\"><jats:title>Conclusion:<\/jats:title><jats:p>Chemoradiotherapy offers similar survivorship compared to surgery in advanced disease, while also making larynx preservation feasible. It can be used as a treatment in all patients as an alternative to surgery.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118000555","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:35:07Z","timestamp":1528792507000},"page":"385-400","source":"Crossref","is-referenced-by-count":41,"title":["Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments"],"prefix":"10.1017","volume":"132","author":[{"given":"A","family":"Habib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"S0022215118000555_ref22","unstructured":"Cochrane Library. In: http:\/\/www.cochranelibrary.com\/ [6 January 2017]"},{"key":"S0022215118000555_ref27","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-91"},{"key":"S0022215118000555_ref37","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701387116"},{"key":"S0022215118000555_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh308"},{"key":"S0022215118000555_ref43","unstructured":"American Society of Anesthesiologists. ASA Physical Status Classification System. In: https:\/\/www.asahq.org\/resources\/clinical-information\/asa-physical-status-classification-system [21 February 2018]"},{"key":"S0022215118000555_ref50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"S0022215118000555_ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S0022215118000555_ref47","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.1990"},{"key":"S0022215118000555_ref36","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5088-4"},{"key":"S0022215118000555_ref2","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010"},{"key":"S0022215118000555_ref19","unstructured":"PubMed, US National Library of Medicine, National Institutes of Health. In: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/ [5 January 2017]."},{"key":"S0022215118000555_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1101"},{"key":"S0022215118000555_ref12","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","volume":"324","author":"Wolf","year":"1991","journal-title":"N Engl J Med"},{"key":"S0022215118000555_ref33","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199705000-00017"},{"key":"S0022215118000555_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10661"},{"key":"S0022215118000555_ref38","first-page":"15","article-title":"Treatment of advanced hypopharyngeal cancer - comparison of two modalities","volume":"18","author":"Hung","year":"2006","journal-title":"Tzu Chi Med J"},{"key":"S0022215118000555_ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.008"},{"key":"S0022215118000555_ref26","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.968673"},{"key":"S0022215118000555_ref30","unstructured":"STROBE Statement. Strengthening the reporting of observational studies in epidemiology. In: https:\/\/www.strobe-statement.org\/index.php?id=available-checklists [20 January 2017]"},{"key":"S0022215118000555_ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.0659"},{"key":"S0022215118000555_ref58","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.6309"},{"key":"S0022215118000555_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80105-9"},{"key":"S0022215118000555_ref44","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2005.0020"},{"key":"S0022215118000555_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318173dc4a"},{"key":"S0022215118000555_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000158348.38763.5D"},{"key":"S0022215118000555_ref21","unstructured":"Scopus. In: https:\/\/www.scopus.com\/home.uri [6 January 2017]"},{"key":"S0022215118000555_ref3","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"S0022215118000555_ref11","first-page":"890","article-title":"Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial","volume":"88","author":"Lefebvre","year":"1996","journal-title":"EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst"},{"key":"S0022215118000555_ref18","unstructured":"American Joint Committee on Cancer. Manual for Staging of Cancer, 3rd edn. Philadelphia: Lippincott, 1988."},{"key":"S0022215118000555_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199708000-00001"},{"key":"S0022215118000555_ref42","unstructured":"Karnofsky Performance Status Scale Definitions Rating (%) Criteria. In: http:\/\/www.hospicepatients.org\/karnofsky.html [21 February 2018]"},{"key":"S0022215118000555_ref5","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198708000-00002"},{"key":"S0022215118000555_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199812)20:8<714::AID-HED9>3.0.CO;2-2"},{"key":"S0022215118000555_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21613"},{"key":"S0022215118000555_ref9","doi-asserted-by":"publisher","DOI":"10.1590\/0100-3984.2015.0018"},{"key":"S0022215118000555_ref57","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830101)51:1<15::AID-CNCR2820510105>3.0.CO;2-2"},{"key":"S0022215118000555_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20107"},{"key":"S0022215118000555_ref17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2273.2002.00570.x","article-title":"Evidence-based management of hypopharyngeal cancer","volume":"27","author":"Robson","year":"2002","journal-title":"Clin Otolaryngol"},{"key":"S0022215118000555_ref20","unstructured":"Embase (produced by Elsevier). In: https:\/\/www.elsevier.com\/solutions\/embase-biomedical-research [6 January 2017]."},{"key":"S0022215118000555_ref23","unstructured":"Ovid technologies (Wolters Kluwer). In: http:\/\/www.ovid.com\/site\/index.jsp [7 January 2017]"},{"key":"S0022215118000555_ref28","unstructured":"Equator Network. Enhancing the QUAlity and Transparency Of health Research. In: http:\/\/www.equator-network.org\/ [20 January 2017]"},{"key":"S0022215118000555_ref24","unstructured":"RefWorks. In: https:\/\/www.refworks.com\/refworks2\/default.aspx?r=authentication::init [7 January 2017]"},{"key":"S0022215118000555_ref29","unstructured":"CONSORT 2010. In: http:\/\/www.consort-statement.org\/consort-2010 [20 January 2017]"},{"key":"S0022215118000555_ref31","unstructured":"Review Manager (RevMan) [computer program]. Version 5.3. Copenhagen: Nordic Cochrane Centre, Cochrane Collaboration, 2014."},{"key":"S0022215118000555_ref32","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"S0022215118000555_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199609\/10)18:5<405::AID-HED3>3.0.CO;2-9"},{"key":"S0022215118000555_ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-37"},{"key":"S0022215118000555_ref35","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.340"},{"key":"S0022215118000555_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90011-4"},{"key":"S0022215118000555_ref14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.8.1652"},{"key":"S0022215118000555_ref48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070956"},{"key":"S0022215118000555_ref49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071028"},{"key":"S0022215118000555_ref51","doi-asserted-by":"publisher","DOI":"10.3109\/00016480902914080"},{"key":"S0022215118000555_ref52","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.0906"},{"key":"S0022215118000555_ref53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"S0022215118000555_ref54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"},{"key":"S0022215118000555_ref55","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860215)57:4<711::AID-CNCR2820570405>3.0.CO;2-C"},{"key":"S0022215118000555_ref56","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850301)55:5<1123::AID-CNCR2820550530>3.0.CO;2-8"},{"key":"S0022215118000555_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70011-1"},{"key":"S0022215118000555_ref60","first-page":"4523","article-title":"Resistance patterns between cis-diamminedichloroplatinum (II) and ionizing radiation","volume":"51","author":"De Pooter","year":"1991","journal-title":"Cancer Res"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215118000555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T20:58:22Z","timestamp":1555275502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215118000555\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0022215118000555"],"URL":"https:\/\/doi.org\/10.1017\/s0022215118000555","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}