{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:46:42Z","timestamp":1787042802893,"version":"build-2736575974"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118000592_sec_a1\"><jats:title>Objective:<\/jats:title><jats:p>This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000592_sec_a2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000592_sec_a3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Submandibular gland involvement, via direct invasion from the anatomical proximity of T<jats:sub>4a<\/jats:sub> tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (<jats:italic>p<\/jats:italic> = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118000592_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>The results suggest the feasibility of preserving the submandibular gland in early stage oral cavity carcinoma unless the tumour is located in, or extends to, the floor of mouth.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118000592","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T06:30:00Z","timestamp":1525329000000},"page":"446-451","source":"Crossref","is-referenced-by-count":21,"title":["Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma"],"prefix":"10.1017","volume":"132","author":[{"given":"A","family":"Cakir Cetin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ozay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Kumus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T K","family":"Erdag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Karabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sarioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A O","family":"Ikiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"S0022215118000592_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(03)00023-9"},{"key":"S0022215118000592_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000064"},{"key":"S0022215118000592_ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00111"},{"key":"S0022215118000592_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21039"},{"key":"S0022215118000592_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70180-8"},{"key":"S0022215118000592_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00009"},{"key":"S0022215118000592_ref16","first-page":"88","article-title":"Is it necessary to remove submandibular glands in squamous cell carcinomas of the oral cavity?","volume":"33","author":"Basaran","year":"2013","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"S0022215118000592_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111001095"},{"key":"S0022215118000592_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203404"},{"key":"S0022215118000592_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-014-0803-6"},{"key":"S0022215118000592_ref8","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010"},{"key":"S0022215118000592_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.02.006"},{"key":"S0022215118000592_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<207::AID-HED1>3.0.CO;2-9"},{"key":"S0022215118000592_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01378-8"},{"key":"S0022215118000592_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21129"},{"key":"S0022215118000592_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.11.018"},{"key":"S0022215118000592_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20109"},{"key":"S0022215118000592_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4205-0"},{"key":"S0022215118000592_ref22","first-page":"565","article-title":"Submandibular gland involvement in early stage oral cavity carcinomas: can the gland be left behind?","volume":"24","author":"Ashfaq","year":"2014","journal-title":"J Coll Physicians Surg Pak"},{"key":"S0022215118000592_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111002660"},{"key":"S0022215118000592_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.02.001"},{"key":"S0022215118000592_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181be87a3"},{"key":"S0022215118000592_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802032801"},{"key":"S0022215118000592_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2016.09.008"},{"key":"S0022215118000592_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114000267"},{"key":"S0022215118000592_ref20","first-page":"521","article-title":"Involvement of the submandibular region in epidermoid carcinoma of the mouth floor. 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