{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:46:26Z","timestamp":1761896786499},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The present study aimed to compare the anti-biofilm activities of four commonly available antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus<\/jats:italic> and quinolone-resistant Pseudomonas aeruginosa in vitro<\/jats:italic>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The anti-biofilm activities of 50 per cent Burow's solution, vinegar with water (1:1), 2 per cent acetic acid solution, and 4 per cent boric acid solution were evaluated using biofilm assays. Additionally, the anti-biofilm activities of the four antiseptic solutions against tympanostomy tube biofilms were compared using a scanning electron microscope.<\/jats:p><\/jats:sec>Results<\/jats:title>The inhibition of biofilm formation from methicillin-resistant S aureus<\/jats:italic> and quinolone-resistant P aeruginosa<\/jats:italic> occurred after treatment with 4 per cent boric acid solution, 2 per cent acetic acid solution, and vinegar with water (1:1). However, 50 per cent Burow's solution did not exhibit effective anti-biofilm activity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results indicate that 4 per cent boric acid solution and vinegar with water (1:1) are potent inhibitors of biofilms from methicillin-resistant S aureus<\/jats:italic> and quinolone-resistant P aeruginosa<\/jats:italic>, and provide safe pH levels for avoiding ototoxicity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118000932","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T06:48:10Z","timestamp":1529304490000},"page":"519-522","source":"Crossref","is-referenced-by-count":12,"title":["Comparative efficacies of topical antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa"],"prefix":"10.1017","volume":"132","author":[{"given":"C K","family":"Youn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Jun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E-R","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-J","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S I","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"S0022215118000932_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.03.007"},{"key":"S0022215118000932_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.03.031"},{"key":"S0022215118000932_ref17","first-page":"382","volume":"32","year":"2016","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"S0022215118000932_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136190"},{"key":"S0022215118000932_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25102"},{"key":"S0022215118000932_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.2.167-193.2002"},{"key":"S0022215118000932_ref14","first-page":"175","volume":"28","year":"2017","journal-title":"Wounds"},{"key":"S0022215118000932_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25826"},{"key":"S0022215118000932_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.12.011"},{"key":"S0022215118000932_ref7","first-page":"713","volume":"130","year":"1994","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"S0022215118000932_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.06.025"},{"key":"S0022215118000932_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.05.025"},{"key":"S0022215118000932_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3607-8"},{"key":"S0022215118000932_ref5","volume-title":"British Pharmacopoeia 2009","year":"2008"},{"key":"S0022215118000932_ref10","doi-asserted-by":"publisher","DOI":"10.1039\/b804469b"},{"key":"S0022215118000932_ref4","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0554"},{"key":"S0022215118000932_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12673"},{"key":"S0022215118000932_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800628"},{"key":"S0022215118000932_ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1251"},{"key":"S0022215118000932_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90032-X"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215118000932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T19:10:58Z","timestamp":1531941058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215118000932\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":20,"journal-issue":{"issue":"06","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0022215118000932"],"URL":"https:\/\/doi.org\/10.1017\/s0022215118000932","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}