{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:28:32Z","timestamp":1777030112339,"version":"3.51.4"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118001494_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To compare post-operative audiometric outcomes for the two prevailing surgical approaches for isolated malleus and\/or incus fixation: ossicular mobilisation with preservation of the ossicular chain, and disruption and reconstruction of the ossicular chain.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001494_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A search was conducted, in December 2016, of PubMed, Scopus, and Cumulative Index to Nursing and Allied Health Literature articles written in English. Papers presenting original data regarding post-operative audiometric outcomes in patients who underwent surgical treatment for malleus and\/or incus fixation with a mobile and intact stapes were included. A risk of bias assessment was performed on the 14 selected papers and a tier system was developed. Meta-analysis was accomplished by comparing pooled rates of surgical success by chi-square test and calculating odds ratios by logistical regression. Analysis was performed using Revman5 and R software.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001494_sec_a3\"><jats:title>Results and conclusion<\/jats:title><jats:p>Analysis of the literature revealed no differences in audiometric outcomes between ossicular chain mobilisation and ossicular chain reconstruction in patients with isolated malleus and\/or incus fixation. A large, prospective study comparing both short- and long-term hearing results for ossicular chain mobilisation and ossicular chain reconstruction in this population may identify whether a difference in outcomes exists between the two approaches.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118001494","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T09:34:41Z","timestamp":1538732081000},"page":"858-865","source":"Crossref","is-referenced-by-count":5,"title":["Ossicular chain mobilisation versus reconstruction in surgery for isolated malleus and\/or incus fixation: systematic review and meta-analysis"],"prefix":"10.1017","volume":"132","author":[{"given":"W L","family":"Crutcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,10,5]]},"reference":[{"key":"S0022215118001494_ref13","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2011"},{"key":"S0022215118001494_ref23","first-page":"184","article-title":"The effect of mobility of ossicles and surgical approach on hearing results in patients with tympanosclerosis","volume":"4","author":"\u00c7elik","year":"2008","journal-title":"Mediterr J Otol"},{"key":"S0022215118001494_ref18","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197602000-00015"},{"key":"S0022215118001494_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318191a66d"},{"key":"S0022215118001494_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1981.tb01784.x"},{"key":"S0022215118001494_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115000973"},{"key":"S0022215118001494_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188380"},{"key":"S0022215118001494_ref11","first-page":"631","article-title":"Surgical treatment of tympanosclerosis","volume":"21","author":"Albu","year":"2000","journal-title":"Am J Otol"},{"key":"S0022215118001494_ref8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/000348940211100309","article-title":"Malleus fixation: clinical and histopathological findings","volume":"111","author":"Harris","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"S0022215118001494_ref2","first-page":"717","article-title":"Malleus ankylosis: a clinical, audiometric, histologic, and surgical study of 123 cases","volume":"20","author":"Vincent","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215118001494_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200409000-00004"},{"key":"S0022215118001494_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16"},{"key":"S0022215118001494_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200103000-00005"},{"key":"S0022215118001494_ref15","first-page":"425","volume-title":"Essential Medical Statistics","volume":"414","author":"Kirkwood","year":"2003"},{"key":"S0022215118001494_ref9","first-page":"398","article-title":"Osseous fixation of the malleus","volume":"71","author":"Guilford","year":"1967","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"S0022215118001494_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0789-3"},{"key":"S0022215118001494_ref22","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197810000-00010"},{"key":"S0022215118001494_ref5","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197608000-00012"},{"key":"S0022215118001494_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3445-0"},{"key":"S0022215118001494_ref16","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2011"},{"key":"S0022215118001494_ref6","doi-asserted-by":"publisher","DOI":"10.3109\/00016487009181864"},{"key":"S0022215118001494_ref1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/00016489850182530","article-title":"Congenital bony fixation of the malleus","volume":"118","author":"Subotic","year":"1998","journal-title":"Acta Otolaryngol"},{"key":"S0022215118001494_ref14","volume-title":"Review Manager (RevMan)","year":"2014"}],"container-title":["The Journal of Laryngology &amp; 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