{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T19:59:27Z","timestamp":1701201567368},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118001652_sec_a1\"><jats:title>Objectives<\/jats:title><jats:p>This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001652_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg\/kg oral steroid.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001652_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg\/ml in the patient group and 2334.52 pg\/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (<jats:italic>p<\/jats:italic>= 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg\/ml and 2451.25 pg\/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (<jats:italic>p<\/jats:italic>= 0.010).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001652_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118001652","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T11:11:46Z","timestamp":1538392306000},"page":"891-895","source":"Crossref","is-referenced-by-count":2,"title":["The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps"],"prefix":"10.1017","volume":"132","author":[{"given":"A","family":"Ekinci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"S0022215118001652_ref12","first-page":"220","article-title":"The expression and role of MIF, NF-\u03baB and IL-1\u03b2 in nasal polyps [in Chinese]","volume":"30","author":"Li","year":"2016","journal-title":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"S0022215118001652_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nri1200"},{"key":"S0022215118001652_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401748"},{"key":"S0022215118001652_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.05.016"},{"key":"S0022215118001652_ref19","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1393"},{"key":"S0022215118001652_ref1","first-page":"609","volume-title":"Nasal Polyps, Otolaryngology, Head and Neck Surgery","author":"Koc","year":"2004"},{"key":"S0022215118001652_ref15","first-page":"1455","article-title":"MIF attenuates the suppressive effect of dexamethasone on IL-6 production by nasal polyp","volume":"17","author":"Stathas","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"S0022215118001652_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.002"},{"key":"S0022215118001652_ref23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500243200"},{"key":"S0022215118001652_ref8","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1820001"},{"key":"S0022215118001652_ref3","volume-title":"Nasal Polyps: Epidemiology, Pathogenesis and Treatment","author":"Settipane","year":"1997"},{"key":"S0022215118001652_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-005-0243-8"},{"key":"S0022215118001652_ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1524"},{"key":"S0022215118001652_ref21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1274"},{"key":"S0022215118001652_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300306"},{"key":"S0022215118001652_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/377068a0"},{"key":"S0022215118001652_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300706"},{"key":"S0022215118001652_ref7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1895"},{"key":"S0022215118001652_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"S0022215118001652_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0168-3"},{"key":"S0022215118001652_ref18","first-page":"23","article-title":"Effects of topical mometasone furoate therapy on local and systemic macrophage migration inhibitory factor levels in allergic rhinitis patients [in Turkish]","volume":"6","author":"Kozac\u0131","year":"2005","journal-title":"Meandros Med Dent J"},{"key":"S0022215118001652_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01560-5"},{"key":"S0022215118001652_ref14","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.4049\/jimmunol.154.8.3863","article-title":"Cloning and characterization of the gene for mouse macrophage migration inhibitory factor (MIF)","volume":"154","author":"Mitchell","year":"1995","journal-title":"J Immunol"}],"container-title":["The Journal of Laryngology &amp; 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