{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:45:13Z","timestamp":1790981113395,"version":"4.1.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118001779_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to present the clinical features and surgical outcomes of juvenile nasopharyngeal angiofibroma patients who were surgically treated.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001779_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The medical records of 48 male patients histologically confirmed as having juvenile nasopharyngeal angiofibroma, who underwent transnasal endoscopic surgery between 2005 and 2016, were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001779_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The overall recurrence rate was 20.8 per cent; however, the recurrence rate differed significantly between patients diagnosed aged less than 14 years (34.7 per cent) and more than 14 years (8 per cent) (<jats:italic>p<\/jats:italic> &lt; 0.05). Advanced-stage tumours (Radkowski stage of IIC or more, and \u00d6nerci stage of III or more) were more aggressive than earlier stage tumours (<jats:italic>p<\/jats:italic> &lt; 0.05 and <jats:italic>p<\/jats:italic> &lt; 0.01, respectively). Pre-operative embolisation significantly prolonged mean hospitalisation duration, but had no effect on intra-operative blood loss in patients with advanced-stage tumours (<jats:italic>p<\/jats:italic> &lt; 0.001 and <jats:italic>p<\/jats:italic> = 0.09, respectively).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001779_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The findings show that transnasal endoscopic surgery could be considered the treatment of choice for juvenile nasopharyngeal angiofibroma. Patients diagnosed when aged less than 14 years and those with advanced-stage tumours are at risk of recurrence, and should be monitored with extreme care.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118001779","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T05:06:51Z","timestamp":1540184811000},"page":"978-983","source":"Crossref","is-referenced-by-count":20,"title":["Juvenile nasopharyngeal angiofibroma: a single centre's 11-year experience"],"prefix":"10.1017","volume":"132","author":[{"given":"A E","family":"Pamuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E","family":"S\u00fcsl\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Akg\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"\u00d6nerci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"S0022215118001779_ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00611.x"},{"key":"S0022215118001779_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890140012004"},{"key":"S0022215118001779_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.11.005"},{"key":"S0022215118001779_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20775"},{"key":"S0022215118001779_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992726"},{"key":"S0022215118001779_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198702000-00013"},{"key":"S0022215118001779_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00027"},{"key":"S0022215118001779_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050092"},{"key":"S0022215118001779_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000143970.19992.64"},{"key":"S0022215118001779_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.10.015"},{"key":"S0022215118001779_ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600818138"},{"key":"S0022215118001779_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24522"},{"key":"S0022215118001779_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200007010-00006"},{"key":"S0022215118001779_ref7","first-page":"39","article-title":"Juvenile nasopharyngeal angiofibroma: a revised staging system","volume":"44","author":"Onerci","year":"2006","journal-title":"Rhinology"},{"key":"S0022215118001779_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-015-0374-2"},{"key":"S0022215118001779_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00003"},{"key":"S0022215118001779_ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-25322"},{"key":"S0022215118001779_ref10","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3443"},{"key":"S0022215118001779_ref15","first-page":"56","article-title":"Analysis of risk factors associated with recurrence of nasopharyngeal angiofibroma","volume":"39","author":"Sun","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215118001779_ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/412545"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215118001779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T15:17:52Z","timestamp":1555168672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215118001779\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0022215118001779"],"URL":"https:\/\/doi.org\/10.1017\/s0022215118001779","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]}}}