{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:49Z","timestamp":1791330949946,"version":"4.3.1"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118001846_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Perforations of the tympanic membrane are treated with various surgical techniques and materials. This study aimed to determine the efficacy of platelet-rich plasma during underlay myringoplasty.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001846_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The study included 40 patients. Autologous platelet-rich plasma was applied in-between temporalis fascia graft and tympanic membrane remnant during underlay myringoplasty in group 1 (<jats:italic>n<\/jats:italic> = 20). The outcome was evaluated after three months and compared with group 2 (<jats:italic>n<\/jats:italic> = 20), a control group that underwent routine underlay tympanoplasty.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001846_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>After three months\u2019 follow up, graft uptake was 95 per cent in group 1 and 85 per cent in group 2 (<jats:italic>p<\/jats:italic> &lt; 0.03). Mean hearing threshold gain was 18.62 dB in group 1 and 13.15 dB in group 2. This difference was statistically significant (<jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118001846_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Platelet-rich plasma, with its ease of preparation technique, availability, low cost, autologous nature and good graft uptake rate, justifies its use in tympanoplasty type I procedures.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118001846","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T09:19:39Z","timestamp":1540804779000},"page":"990-994","source":"Crossref","is-referenced-by-count":24,"title":["Studying the result of underlay myringoplasty using platelet-rich plasma"],"prefix":"10.1017","volume":"132","author":[{"given":"S P S","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Gulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Ranga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"S0022215118001846_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.06.002"},{"key":"S0022215118001846_ref10","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0062"},{"key":"S0022215118001846_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31817e793f"},{"key":"S0022215118001846_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000249726.98801.77"},{"key":"S0022215118001846_ref23","first-page":"547","article-title":"Technique for producing platelet-rich plasma and platelet concentrate: background and process","volume":"22","author":"Gonshor","year":"2002","journal-title":"Int J Periodontics Restorative Dent"},{"key":"S0022215118001846_ref20","unstructured":"Platelet Rich Fibrin for the Repair of Tympanic Membrane. 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