{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:35:27Z","timestamp":1777473327025,"version":"3.51.4"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118002062_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002062_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Patients were prospectively recruited between May 2017 and June 2018. Inclusion criteria stipulated biopsy-proven metastatic cervical squamous cell carcinoma, with negative findings on magnetic resonance imaging and positron emission tomography\/computed tomography, in addition to examination under anaesthetic, tonsillectomy and \u2018blind\u2019 tongue base biopsies without tumour identification, prior to mucosectomy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002062_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of nine patients, a mucosal primary was identified in four (44.4 per cent), for which ipsilateral intensity-modulated radiotherapy was advocated in three and completion tongue base resection in the fourth. Dysplasia was demonstrated in two further patients, which provided information relevant to radiotherapy fields and post-treatment surveillance. No surgical complications were identified.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002062_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Tongue base mucosectomy using electrocautery and conventional tonsillectomy equipment is a safe, effective technique in the identification of cervical metastasis from an unknown primary site. It expands the potential breadth of use, quickens prolonged diagnostic pathways and obviates the necessity for pan-mucosal irradiation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118002062","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T10:46:42Z","timestamp":1542710802000},"page":"1138-1142","source":"Crossref","is-referenced-by-count":11,"title":["Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique"],"prefix":"10.1017","volume":"132","author":[{"given":"C R","family":"Davies-Husband","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"S0022215118002062_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23931"},{"key":"S0022215118002062_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23372"},{"key":"S0022215118002062_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23562"},{"key":"S0022215118002062_ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.64719"},{"key":"S0022215118002062_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21898"},{"key":"S0022215118002062_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109000818"},{"key":"S0022215118002062_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20638"},{"key":"S0022215118002062_ref6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00405-002-0470-1","article-title":"Diagnostic strategies in cervical carcinoma of an unknown primary (CUP)","volume":"259","author":"Haas","year":"2002","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215118002062_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000591"},{"key":"S0022215118002062_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12860"},{"key":"S0022215118002062_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00172-9"},{"key":"S0022215118002062_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.3419"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215118002062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T16:11:27Z","timestamp":1605456687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215118002062\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0022215118002062"],"URL":"https:\/\/doi.org\/10.1017\/s0022215118002062","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]}}}