{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:49:41Z","timestamp":1761896981323},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215118002268_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Adenoid hypertrophy is a common cause of upper airway obstruction, and adenoidectomy is one of the most frequently performed operations in children. Topical nasal steroids can act directly on nasopharyngeal lymphoid tissue to decrease its reactive inflammatory changes and potentially reduce its size.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002268_sec_a2\"><jats:title>Objective<\/jats:title><jats:p>To study the light microscopic changes in adenoidal lymphoid tissue after one month of topical steroid use.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002268_sec_a3\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Twenty-six children with adenoid hypertrophy grade 3 scheduled for adenoidectomy were randomly divided into two equal groups: one group received mometasone furoate aqueous nasal spray (Nasonex) 100 mcg\/day for four weeks, and a control group received nasal normal saline 0.9 per cent for four weeks. The removed adenoids were examined histopathologically.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002268_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Adenoidal tissue from the mometasone group had less reactive germinal centres and less spongiosis compared to the control group. The latter showed proliferating, reactive, variable sized and shaped lymphoid follicles, with congested blood vessels in the interfollicular areas.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215118002268_sec_a5\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The use of intranasal mometasone furoate aqueous nasal spray (Nasonex) for one month reduced adenoidal tissue reactive cellular changes and its vascularity. This is, however, a pilot study; a longer treatment period is needed to assess the effect of treatment on adenoidal size.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215118002268","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T19:36:07Z","timestamp":1546976167000},"page":"106-109","source":"Crossref","is-referenced-by-count":7,"title":["Effect of topical mometasone furoate on adenoidal lymphoid tissue: a light microscopic study"],"prefix":"10.1017","volume":"133","author":[{"given":"M R","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Abou-Halawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I H","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Zittoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E F Y","family":"Makary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"S0022215118002268_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01808.x"},{"key":"S0022215118002268_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.04.001"},{"key":"S0022215118002268_ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02907627","article-title":"X-rays in the evaluation of adenoid hypertrophy: it's role in the endoscopic era","volume":"57","author":"Kurien","year":"2005","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"S0022215118002268_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.11.008"},{"key":"S0022215118002268_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.02.052"},{"key":"S0022215118002268_ref10","first-page":"844","article-title":"Systematic reviews on efficacy and safety of beclomethasone nasal spray in the treatment of chronic adenoid hypertrophy in children [in Chinese]","volume":"90","author":"Mi","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"S0022215118002268_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.015"},{"key":"S0022215118002268_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)90037-4"},{"key":"S0022215118002268_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0161-3"},{"key":"S0022215118002268_ref3","first-page":"463","article-title":"Morphofunctional organization of lymphoepithelial organs of the human pharynx [in Russian]","author":"Bykova","year":"2002","journal-title":"Izv Akad Nauk Ser Biol"},{"key":"S0022215118002268_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/00034894921010S106"},{"key":"S0022215118002268_ref1","first-page":"237","article-title":"The Waldeyer's ring","volume":"54","author":"Hellings","year":"2000","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"S0022215118002268_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.07.009"},{"key":"S0022215118002268_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.08.013"},{"key":"S0022215118002268_ref16","first-page":"64","article-title":"Cell dynamics in the germinal center of the human tonsil","volume":"523","author":"Tabe","year":"1996","journal-title":"Acta Otolaryngol Suppl"},{"key":"S0022215118002268_ref18","first-page":"CD006286","article-title":"Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy","volume":"3","author":"Zhang","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215118002268_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.005"},{"key":"S0022215118002268_ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000024354"},{"key":"S0022215118002268_ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/603493"},{"key":"S0022215118002268_ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.3.e236"},{"key":"S0022215118002268_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.6.641"}],"container-title":["The Journal of Laryngology &amp; 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