{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:55:02Z","timestamp":1775562902618,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"03","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"unspecified","delay-in-days":45,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119000549_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Ki-67 is a monoclonal antibody that provides a means of evaluating the growth fraction of normal and neoplastic human cell populations. A Ki-67 index of less than 3 per cent is expected for a typical schwannoma. Vestibular schwannomas with an index of greater than 3 per cent are presumed to be actively proliferating and pose a theoretically higher risk for regrowth or recurrence.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119000549_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted. Ki-67 staining was performed and specimens were divided into two groups according to Ki-67 activity: less than 3 per cent (low index), and 3 per cent or greater (elevated index).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119000549_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Eight patients (53.3 per cent) with elevated Ki-67 had recurrence or regrowth, versus five (8.5 per cent) in the low Ki-67 group. Among the 13 patients with recurrence or regrowth, the average Ki-67 value was 4.3 per cent. Among the 61 patients without recurrence or regrowth, the average Ki-67 value was 1.0 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119000549_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The Ki-67 labelling index reliably identifies vestibular schwannomas with an elevated potential for recurrence or regrowth in subtotal or total resection cases. In patients with a Ki-67 index greater than 3 per cent, more frequent clinical examination and radiological follow up are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119000549","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:25:18Z","timestamp":1555323918000},"page":"205-207","source":"Crossref","is-referenced-by-count":29,"title":["Ki-67 index as a predictor of vestibular schwannoma regrowth or recurrence"],"prefix":"10.1017","volume":"133","author":[{"given":"J","family":"Prueter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Norvell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Backous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"S0022215119000549_ref25","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.111356"},{"key":"S0022215119000549_ref1","first-page":"121","volume":"116","year":"1954","journal-title":"Acta Otolaryngol Suppl (Stockh)"},{"key":"S0022215119000549_ref23","first-page":"191","volume":"66","year":"2014","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"S0022215119000549_ref22","doi-asserted-by":"publisher","DOI":"10.3171\/2010.11.JNS10257"},{"key":"S0022215119000549_ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301395"},{"key":"S0022215119000549_ref20","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.46.176"},{"key":"S0022215119000549_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182976552"},{"key":"S0022215119000549_ref18","doi-asserted-by":"publisher","DOI":"10.3171\/2010.11.JNS101041"},{"key":"S0022215119000549_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01598-5"},{"key":"S0022215119000549_ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2014.2.JNS131497"},{"key":"S0022215119000549_ref15","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.3.489"},{"key":"S0022215119000549_ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1056973"},{"key":"S0022215119000549_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100031243"},{"key":"S0022215119000549_ref8","first-page":"772","volume-title":"Diagnostic Immunohistochemistry: Theranostic and Genomic Applications","year":"2019"},{"key":"S0022215119000549_ref13","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.36.698"},{"key":"S0022215119000549_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198102193040803"},{"key":"S0022215119000549_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200111000-00036"},{"key":"S0022215119000549_ref6","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","volume":"133","year":"1984","journal-title":"J Immunol"},{"key":"S0022215119000549_ref11","first-page":"616","volume":"16","year":"1995","journal-title":"Am J Otol"},{"key":"S0022215119000549_ref5","first-page":"1445","volume-title":"Robbins\u2019 Pathologic Basis of Disease","year":"1989"},{"key":"S0022215119000549_ref10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.4.0807"},{"key":"S0022215119000549_ref4","first-page":"199","volume-title":"Acoustic Neuroma: Proceedings of the First International Conference on Acoustic Neuroma, Copenhagen, Denmark, August 25\u201329, 1991","year":"1992"},{"key":"S0022215119000549_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310201013"},{"key":"S0022215119000549_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.13.4.271"},{"key":"S0022215119000549_ref24","first-page":"389","volume":"21","year":"2000","journal-title":"Am J Otol"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215119000549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T19:11:03Z","timestamp":1694805063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215119000549\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":25,"journal-issue":{"issue":"03","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0022215119000549"],"URL":"https:\/\/doi.org\/10.1017\/s0022215119000549","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}