{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:22:12Z","timestamp":1793766132681,"version":"4.6.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"06","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119001014_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001014_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001014_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001014_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119001014","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T06:07:16Z","timestamp":1558073236000},"page":"466-476","source":"Crossref","is-referenced-by-count":2,"title":["The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma"],"prefix":"10.1017","volume":"133","author":[{"given":"F C","family":"Akin Ocal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G G","family":"Kesici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Gurgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ocal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Erbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"S0022215119001014_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00391-4"},{"key":"S0022215119001014_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.07.052"},{"key":"S0022215119001014_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2978-x"},{"key":"S0022215119001014_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2011.07.001"},{"key":"S0022215119001014_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.02.010"},{"key":"S0022215119001014_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.01.021"},{"key":"S0022215119001014_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.11.026"},{"key":"S0022215119001014_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.03.029"},{"key":"S0022215119001014_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02733-5"},{"key":"S0022215119001014_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00311.2002"},{"key":"S0022215119001014_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.10.006"},{"key":"S0022215119001014_ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00401.2004"},{"key":"S0022215119001014_ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000013847"},{"key":"S0022215119001014_ref10","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2013.57"},{"key":"S0022215119001014_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010043"},{"key":"S0022215119001014_ref3","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.960076"},{"key":"S0022215119001014_ref2","first-page":"505","volume":"21","year":"2000","journal-title":"Am J Otol"},{"key":"S0022215119001014_ref1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2008.1.2.80"},{"key":"S0022215119001014_ref26","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.16.2.2"},{"key":"S0022215119001014_ref25","first-page":"1","volume":"27","year":"2006","journal-title":"Ear Hear"},{"key":"S0022215119001014_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114761"},{"key":"S0022215119001014_ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000241896"},{"key":"S0022215119001014_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03574-9"},{"key":"S0022215119001014_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114002680"},{"key":"S0022215119001014_ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000071061"},{"key":"S0022215119001014_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00286-1"}],"container-title":["The Journal of Laryngology &amp; 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