{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:52:29Z","timestamp":1747173149340,"version":"3.40.5"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221511900104X_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To determine whether central findings from vestibular tests predict abnormal findings on magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511900104X_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This study was a retrospective case series at a tertiary referral centre. The main outcome measure of this diagnostic intervention study was the positive predictive value of central vestibular findings in relation to magnetic resonance imaging abnormalities.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511900104X_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Central vestibular findings had a 50.9 per cent positive predictive value for magnetic resonance imaging abnormalities across all age groups although they varied according to age group. Optokinetic nystagmus (<jats:italic>p<\/jats:italic> &lt; 0.05) and abnormal findings on videonystagmography tests (<jats:italic>p<\/jats:italic> &lt; 0.05) were the main predictors of magnetic resonance imaging abnormalities. White matter lesions constituted the bulk of the central lesions on magnetic resonance imaging followed by cortical and cerebellar atrophy.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511900104X_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Central vestibular findings had a 50.9 per cent positive predictive value for magnetic resonance imaging abnormalities across all age groups. Magnetic resonance imaging is medically justified to further evaluate patients with central findings on vestibular studies. Therefore, it is reasonable to request magnetic resonance imaging in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511900104x","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T04:57:34Z","timestamp":1560488254000},"page":"554-559","source":"Crossref","is-referenced-by-count":3,"title":["Do central vestibular findings predict abnormal findings on magnetic resonance imaging?"],"prefix":"10.1017","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-6622","authenticated-orcid":false,"given":"G","family":"Mankekar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Jeha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Erbele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Klumpp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sevy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Arriaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"S002221511900104X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2011.01.008"},{"key":"S002221511900104X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2017.09.038"},{"key":"S002221511900104X_ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000049147"},{"key":"S002221511900104X_ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00369.x"},{"key":"S002221511900104X_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11498"},{"key":"S002221511900104X_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.9.1366"},{"key":"S002221511900104X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.002"},{"key":"S002221511900104X_ref6","doi-asserted-by":"publisher","DOI":"10.4103\/1012-5574.186534"},{"key":"S002221511900104X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70221-8"},{"key":"S002221511900104X_ref4","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10003-1089"},{"key":"S002221511900104X_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24532"},{"volume-title":"Clinical Neurophysiology of the Vestibular System","year":"2011","author":"Baloh","key":"S002221511900104X_ref17"},{"key":"S002221511900104X_ref19","first-page":"341","article-title":"Retrospective blinded review of magnetic resonance imaging in patients with central electronystagmography findings","volume":"19","author":"Kinney","year":"1998","journal-title":"Am J Otol"},{"key":"S002221511900104X_ref18","first-page":"337","volume-title":"Neurology and Clinical Neuroscience","author":"Luxon","year":"2007"},{"key":"S002221511900104X_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31817533a3"},{"key":"S002221511900104X_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.09.006"},{"key":"S002221511900104X_ref15","first-page":"2786","article-title":"White matter lesions and vascular vertigo: clinical correlation and findings on cranial magnetic resonance imaging","volume":"20","author":"Gamba","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"S002221511900104X_ref9","first-page":"207","volume-title":"Practical Neurology","author":"Hain","year":"2017"},{"key":"S002221511900104X_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.5.587"},{"key":"S002221511900104X_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.024"},{"key":"S002221511900104X_ref13","first-page":"7701","article-title":"Recent progress on small vessel disease with cognitive impairment","volume":"8","author":"Gong","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"S002221511900104X_ref7","first-page":"157","article-title":"Association between complaints of dizziness and hypertension in non-institutionalized elders","volume":"17","author":"Lopes","year":"2013","journal-title":"Int Arch Otorhinolaryngol"}],"container-title":["The Journal of Laryngology &amp; 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